Publications with BibTex Formatting
@article{Trillo1992,
author = {Trillo, A and Orozco, R and Jindal, K.},
title = {Glomerular calcinosis in sarcoidosis.},
journal = {Arch Pathol Lab Med},
year = {1992},
volume = {116},
pages = {1221-1225},
number = {11},
month = {Nov.},
lu_pub_type = {a_article},
display_order = {1},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Trillo1992.pdf},
abstract = {Glomerular lesions secondary to calcium deposition in sarcoidosis
have not been previously described, to our knowledge. Five renal
biopsy specimens from four patients with sarcoidosis were studied
by light, electron, and immunofluorescence microscopy. In addition
to interstitial granulomatous nephritis and nephrocalcinosis, which
were seen in all cases, segmental glomerular lesions characterized
by marked thickening and wrinkling of the glomerular capillary walls
and basophilic appearance of the altered basement membranes were
present in three of the cases. Electron microscopic examination of
the lesions revealed dramatic alteration of the glomerular ultrastructure.
Numerous single and coalescent calcific microspherules were present
within the basement membrane, the paramesangial zone, and the mesangium.
The findings of immunofluorescence were noncontributory. The structural
alterations caused by calcinosis of the glomerulus may be responsible
for some of the frequent renal function abnormalities seen in sarcoidosis.},
file = {Trillo1992.pdf:Trillo1992.pdf:PDF},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1280079}
}
@article{Ho1993,
author = {Ho, D. S. and Patterson, A. L. and Orozco, R. E. and Murphy, W. M.},
title = {Extramedullary plasmacytoma of the bladder: Case report and review
of the literature.},
journal = {J Urol.},
year = {1993},
volume = {150},
pages = {473-474},
number = {2 Pt 1},
month = {Aug.},
lu_pub_type = {a_article},
display_order = {1},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Ho1993.pdf},
abstract = {Primary plasmacytoma of the bladder is extremely rare, with only 10
cases reported in the literature. We report on a patient who was
treated unsuccessfully with radiation and subsequently underwent
anterior exenteration with ileo-conduit construction.},
file = {Ho1993.pdf:Ho1993.pdf:PDF},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8326583}
}
@article{Orozco1993a,
author = {Orozco, R. E. and Murphy, W. M.},
title = {Carcinoma of the rete testis: Case report and review of the literature.},
journal = {J Urol},
year = {1993},
volume = {150},
pages = {974-977},
number = {3},
month = {Sep.},
lu_pub_type = {a_article},
display_order = {1},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1993a.pdf},
abstract = {The literature suggests that carcinoma of the rete testis is a rare
neoplasm of unknown etiology that arises in the mediastinum testis
and may grow slowly for months before clinical detection. Diagnosis
is often confounded by symptoms suggesting inflammation in middle
aged and older men presenting with diffuse enlargement rather than
discrete testicular nodules. Pathological features are those of an
adenocarcinoma but are not sufficiently distinctive to identify the
rete testis as the site of origin. Many patients die of the disease
soon after diagnosis despite local resection with or without adjuvant
therapy. Long-term survival has been observed in at least 2 cases
and more than 40\% of the patients were alive without disease when
reported in the literature. Much of the available information is
incomplete, however, and firm conclusions regarding the nature of
this cancer must await more solid data.},
file = {Orozco1993a.pdf:Orozco1993a.pdf:PDF},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8345624}
}
@article{Orozco1993,
author = {Roberto E. Orozco and Roger Vander Zwaag and William M. Murphy},
title = {The pagetoid variant of urothelial carcinoma in situ},
journal = {Human Pathology},
year = {1993},
volume = {24},
pages = {1199 - 1202},
number = {11},
lu_pub_type = {a_article},
display_order = {1},
abstract = {The frequency, distribution, and clinical significance of pagetoid
changes in urothelial carcinoma in situ (CIS) were studied in over
600 tissue slides from 102 patients followed for a mean period of
over 4 years. Results indicate that pagetoid changes are unusual,
randomly distributed, and never widespread. These changes occur in
a histologic setting of CIS and apparently never appear as the initial
lesion, even in cases in which CIS is the primary or only neoplasm.
Patients manifesting pagetoid CIS had essentially the same progression
and survival rates as patients without pagetoid changes. Our data
suggest that this histologic pattern represents a peculiar reaction
to injury confined to small areas of urothelium in susceptible hosts.},
doi = {10.1016/0046-8177(93)90216-4},
file = {Orozco1993.pdf:Orozco1993.pdf:PDF},
issn = {0046-8177},
keywords = {pagetoid carcinoma in situ},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.sciencedirect.com/science/article/B6WGD-4C2RXJ9-WJ/2/cba49b9bfaa834c4dfa746ed26f8e8d3}
}
@article{Orozco1994,
author = {Orozco, R. E. and Martin, A. A. and Murphy, W. M.},
title = {Carcinoma in situ of the urinary bladder: Clues to host involvement
in human carcinogenesis},
journal = {Cancer},
year = {1994},
volume = {74},
pages = {115--122},
number = {1},
lu_pub_type = {a_article},
display_order = {1},
abstract = {Abstract: Background. Carcinoma in situ (CIS) of the urinary bladder
is a neoplasm of uncertain biologic behavior. It rarely occurs as
the primary disease and exists most often in association with high
grade, invasive tumors. The unfavorable prognosis ascribed to CIS
may not be due to tumor-related factors but to low host resistance
or to host-tumor relationships established for previous or coincident
invasive cancers. The scant available evidence indicates that a large
proportion of patients with primary CIS have a low frequency of muscle
invasion and death from disease. Methods. Of 2000 patients with bladder
neoplasms in our pathology files and tumor registry, 102 had CIS
confirmed on histologic review. There were 29 cases of primary CIS
and 73 cases of secondary CIS. These cases were compared, with an
emphasis on patient outcome. Results. The data indicate that primary
and secondary CIS are histologically identical lesions whose effect
on patients is related mainly to the presence of multifocal disease,
often associated with previous or coincident invasive cancers. Progression
or death from disease is unusual among patients presenting with primary
CIS but common among individuals with CIS associated with other bladder
cancers. Conclusion. The authors suggest that the appearance of urothelial
CIS identifies patients with at least localized resistance to the
development of invasive bladder cancer. The degree of patient resistance
to carcinogenic events leading to bladder carcinoma is manifested
by the type, grade, and stage of their initial neoplasms.},
doi = {10.1002/1097-0142(19940701)74:1<115::AID-CNCR2820740120>3.0.CO;2-R},
file = {Orozco1994.pdf:Orozco1994.pdf:PDF},
issn = {1097-0142},
keywords = {urothelial carcinoma in situ, carcinoma in situ, transitional cell
carcinoma, bladder cancer, human carcinogenesis, host factors},
owner = {UsuariO},
publisher = {Wiley Subscription Services, Inc., A Wiley Company},
timestamp = {2010.10.02},
url = {http://dx.doi.org/10.1002/1097-0142(19940701)74:1<115::AID-CNCR2820740120>3.0.CO;2-R}
}
@article{Orozco1995,
author = {Orozco, R.E. and Peters, R.L.},
title = {Teflon granuloma of the prostate mimicking adenocarcinoma},
journal = {J Urol Pathol},
year = {1995},
volume = {3},
pages = {365-368},
number = {4},
lu_pub_type = {a_article},
display_order = {1},
owner = {U},
timestamp = {2010.11.15}
}
@article{Algaba1996,
author = {Algaba, F. and Epstein, J. I. and Aldape, H. C. and Farrow, G. M.
and Lopez-Beltran, A. and Maksem, J. and Orozco, R. E. and Pacelli,
A. and Pisansky, T. M. and Trias, I.},
title = {Workgroup 5: Assessment of prostate carcinoma in core needle biopsy--Definition
of minimal criteria for the diagnosis of cancer in biopsy material},
journal = {Cancer},
year = {1996},
volume = {78},
pages = {376--381},
number = {2},
month = {Jul.},
lu_pub_type = {a_article},
display_order = {1},
doi = {10.1002/(SICI)1097-0142(19960715)78:2<376::AID-CNCR32>3.0.CO;2-R},
file = {Algaba1996.pdf:Algaba1996.pdf:PDF},
issn = {1097-0142},
owner = {UsuariO},
publisher = {Wiley Subscription Services, Inc., A Wiley Company},
timestamp = {2010.10.02},
url = {http://dx.doi.org/10.1002/(SICI)1097-0142(19960715)78:2<376::AID-CNCR32>3.0.CO;2-R}
}
@article{ODowd1997,
author = {O'Dowd, Gerard J. and Veltri, Robert W. and Orozco, Roberto and Miller,
M. Craig and Oesterling, Joseph E.},
title = {Update on the appropriate staging evaluation for newly diagnosed
prostate cancer},
journal = {J Urol},
year = {1997},
volume = {158},
pages = {687--698},
number = {3 pt 1},
month = sep,
lu_pub_type = {a_article},
display_order = {1},
abstract = {Prostate cancer clinical staging methods and decision support tools
were reviewed to assess their accuracy to predict pathological staging
results and determine what comprises an appropriate clinical staging
evaluation. The MEDLINE data base was searched and 238 abstracts
were obtained. Data were extracted from 142 articles that evaluated
the preoperative accuracy of digital rectal examination, prostate
specific antigen, prostatic acid phosphatase, systematic biopsy parameters
(including Gleason scoring), seminal vesicle biopsy, various imaging
studies and pelvic lymphadenectomy versus pathological staging results.
The sensitivity, specificity and accuracy rates were calculated and
tabulated from the reported data on each method or decision support
tools for organ confined, nonorgan confined and lymph node metastatic
tumor. Decision support tools based on logistic regression analysis,
which combine several statistically independent staging parameters,
had greater accuracy than any single clinical staging method alone.
The most accurate decision support tools for clinical staging combined
digital rectal examination (T stage), systematic biopsy parameters
(including Gleason scoring) and prostate specific antigen. The components
that comprise the most accurate decision support tools for clinical
staging represent an appropriate staging evaluation for the newly
diagnosed prostate cancer patient in 1997. Limited use of radiographic
imaging and seminal vesicle biopsy may be indicated in select patients
to detect bone metastases, and plan pelvic lymphadenectomy and surgical
therapy.},
file = {ODowd1997.pdf:ODowd1997.pdf:PDF},
issn = {0022-5347},
owner = {UsuariO},
publisher = {Elsevier,},
refid = {S0022-5347(01)64295-2},
timestamp = {2010.10.02},
url = {http://linkinghub.elsevier.com/retrieve/pii/S0022534701642952?showall=true}
}
@article{Orozco1997a,
author = {Orozco, R and O'Dowd, G and Del Villar, R and Vitko, R and De Juana,
C and Feigl, A and Kunnel, B. and Wojcik, E.M.},
title = {Systematic sextant biopsy findings of prostatic adenocarcinoma in
U.S. hispanics and whites},
journal = {J Urol Pathol},
year = {1997},
volume = {6},
pages = {43 - 50},
number = {1},
lu_pub_type = {a_article},
display_order = {1},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1997a.pdf},
file = {Orozco1997a.pdf:Orozco1997a.pdf:PDF},
issn = {1067-1919},
owner = {U},
timestamp = {2010.11.15}
}
@article{Wojcik1997,
author = {Wojcik, E.M. and Orozco, R and O'Dowd, G.J.},
title = {The role of fine needle aspiration of the prostate in the era of
an automated thin needle biopsy gun},
journal = {J Urol Pathol},
year = {1997},
volume = { 7},
pages = {89-97.},
number = {2},
lu_pub_type = {a_article},
display_order = {1},
owner = {U},
timestamp = {2010.11.15}
}
@article{Iczkowski1998,
author = {Iczkowski, Kenneth A. and Bassler, Thomas J. and Schwob, Valerie
S. and Bassler, Ilene C. and Kunnel, Binitha S. and Orozco, Roberto
E. and Bostwick, David G.},
title = {Diagnosis of ``suspicious for malignancy" in prostate biopsies: Predictive
value for cancer},
journal = {Urology},
year = {1998},
volume = {51},
pages = {749--758},
number = {5},
month = may,
lu_pub_type = {a_article},
display_order = {1},
abstract = {Objectives. Prostate needle biopsies occasionally contain an atypical
small acinar proliferation (ASAP) that is suspicious for but not
diagnostic of malignancy. The predictive value of ASAP for cancer
has not been studied in a large series. Methods. To determine the
reproducibility and clinical significance of ASAP in a large urologic
reference laboratory, we retrospectively studied 295 patients with
ASAP diagnosed from 1991 to 1995. Each patient had at least one follow-up
biopsy. Mean patient age was 68.0 years (range 40 to 89). Numerous
clinical and histologic features were assessed to determine their
predictive value for malignancy on subsequent biopsy. Results. Adenocarcinoma
was identified on follow-up biopsy in 125 patients (42\%), with a
median follow-up of 5.7 months (range 0.1 to 43). Gleason score varied
from 4 to 9 (mean 6.2). Cumulative detection of 125 cancers was 90\%
after second biopsy and 99\% after third biopsy. Serum prostate-specific
antigen, digital rectal examination result, and patient age were
not predictive of cancer on follow-up biopsy. Likewise, the number
of biopsy cores and histologic findings including number of acini
per focus of ASAP, number of foci of ASAP, degree of nuclear and
nucleolar enlargement, and presence of luminal pink granular secretions,
mucin, or crystalloids were not predictive of cancer. Stratifying
our level of suspicion into three categories (favor benign, uncertain,
and favor carcinoma) did not differentially predict subsequent cancer
(44\%, 44\%, and 41\% of patients, respectively; P = 0.86) nor the
percentage of tissue involved by cancer. No clinical or pathologic
feature affected the likelihood of subsequent cancer. In 39\% of
patients, cancer was only contralateral to or in a different sextant
site from the initial ASAP site. Conclusions. The high predictive
value of ASAP for subsequent adenocarcinoma warrants repeat biopsy.
Sampling should include multiple sites in the prostate.},
file = {Iczkowski1998.pdf:Iczkowski1998.pdf:PDF},
issn = {0090-4295},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.sciencedirect.com/science/article/B6VJW-3VW7NV3-1S/2/e89333544253ded51729a8f10512c7ec}
}
@article{Orozco1998a,
author = {Orozco, Roberto and Kunnel, Binitha and O'Dowd, Gerard J. and Stamey,
Thomas A.},
title = {Positive prostate biopsy rate consistently increases with age at
the same prostate-specific antigen level in patients with normal
digital rectal examination},
journal = {Urology},
year = {1998},
volume = {51},
pages = {531--533},
number = {4},
month = apr,
lu_pub_type = {a_article},
display_order = {1},
abstract = {Objectives. To examine the relationship between positive prostate
biopsy rates and age over the range of serum prostate-specific antigen
(PSA) concentrations of 4 to 10 ng/mL. Methods. The rates for adenocarcinoma
were calculated for prostate biopsy specimens received at UroCor
Inc., Oklahoma City, Oklahoma between April 1995 and June 1997. The
selection criteria were as follows: men between 50 and 79 years of
age, normal digital rectal examination (DRE), prebiopsy PSA level
between 4.01 and 10.0 ng/mL obtained within a 4-month period prior
to receipt of biopsy, and no previous prostate biopsy. Five thousand
six cases were selected out of 81,545 prostate biopsy specimens submitted
by office-based urologists. The rates of positive prostate biopsies
were stratified by age in decade increments and by PSA in increments
of 1 ng/mL. The P values were calculated by the chi-square test.
Results. The patient mean age was 65.8 years. An overall increase
in the positive prostate biopsy rate for men between 50 and 79 years
of age as serum PSA increases from 4.01 to 10.0 ng/mL (P = 0.047)
was found; however, this increase was less significant than the increase
found in positive biopsy rates caused by age alone (P <0.0001). Conclusions.
Undetected prostate cancer appears to be a major cause of the increasing
serum PSA seen with advancing age.},
file = {Orozco1998a.pdf:Orozco1998a.pdf:PDF},
issn = {0090-4295},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.sciencedirect.com/science/article/B6VJW-3VW7NHV-2/2/ea9f100226b27970fba4a54944c3cc04}
}
@article{Orozco1998,
author = {Orozco, Roberto and O'Dowd, Gerard and Kunnel, Binitha and Miller,
M. Craig and Veltri, Robert W.},
title = {Observations on pathology trends in 62,537 prostate biopsies obtained
from urology private practices in the United States},
journal = {Urology},
year = {1998},
volume = {51},
pages = {186--195},
number = {2},
month = feb,
lu_pub_type = {a_article},
display_order = {1},
abstract = {Objectives. To evaluate pathology trends of 62,537 first-time prostate
needle-core biopsies submitted by office-based urologists, processed
at a single pathology laboratory. Methods. Prostate biopsy cases
obtained over a 2-year period were assessed. Patient information
included age, digital rectal examination (DRE) status, and prostate-specific
antigen (PSA) serum levels. Biopsy pathology results included the
number of tissue samples per case, Gleason score, presence of Gleason
grades 4 or 5, percent of biopsy length with evidence of cancer,
number of samples with cancer per biopsy, and determination of DNA
ploidy status using microspectrophotometry. Results. Adenocarcinoma,
suspicious lesions, and isolated high-grade prostatic intraepithelial
neoplasia (PIN) were diagnosed in 38.3\%, 2.9\%, and 4.1\% of the
biopsies, respectively. For each serum PSA and age range assessed,
the positive biopsy rate and incidence of critical pathologic features
increased consistently. The average percentage of biopsy length with
evidence of tumor, the percentage of cases with Gleason grades 4
or 5, and the percentage of cases with an abnormal DNA ploidy all
decreased significantly over the 2-year period (P <0.01). Conclusions.
The number of tissue cores and anatomic sites (locations) being sampled
per biopsy are increasing. The tumor size detected and percentage
of cases with Gleason grades 4 and 5 are decreasing. There has been
a slight increase in the number of biopsies performed on men younger
than 60 years of age and a slight decrease in biopsies performed
on men older than 70 years of age. The decline in meaningful pathologic
features observed in biopsies over time may be clinically relevant
to improved disease management.},
file = {Orozco1998.pdf:Orozco1998.pdf:PDF},
issn = {0090-4295},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.sciencedirect.com/science/article/B6VJW-443YSM5-5G/2/7f773717d8c2b93172b403fffbe6dded}
}
@article{BasslerJr1998,
author = {Thomas J. {Bassler Jr} and Roberto Orozco and Ilene C. Bassler and
Gerard J. O'Dowd and Thomas A. Stamey},
title = {Most prostate cancers missed by raising the upper limit of normal
prostate-specific antigen for men in their sixties are clinically
significant},
journal = {Urology},
year = {1998},
volume = {52},
pages = {1064 - 1069},
number = {6},
month = {Dec.},
lu_pub_type = {a_article},
display_order = {1},
abstract = {Objectives. To evaluate the efficacy of applying an age-specific prostate-specific
antigen (PSA) reference range to determine whether prostate biopsies
are warranted in men 60 to 69 years of age. We estimated the incidence
of clinically significant prostate cancer in men in their sixties
with PSA levels of 4.01 to 4.50 ng/mL and normal digital rectal examinations
(DRE). Methods. We reviewed 203 sextant prostate biopsies of men
in their sixties with PSA levels of 4.01 to 4.50 ng/mL and normal
DRE. Tumors were considered clinically significant if the cancer
on biopsy was poorly differentiated (Gleason score of 7 or more),
involved more than one core, or included a single focus measuring
more than 3 mm. Results. The positive biopsy rate was 31.5\%. More
than 80\% of the cancers detected satisfied criteria that almost
always predict clinically significant cancer. Thus, among men in
their sixties with PSA levels of 4.01 to 4.50 ng/mL and normal DRE,
the risk of detecting clinically significant cancer on biopsy was
approximately 25\%. Conclusions. Most nonpalpable cancers detected
by sextant biopsies in men 60 to 69 years of age with PSA levels
of 4.01 to 4.5 ng/mL are clinically significant. Applying an age-specific
PSA reference range that increases the upper limit of normal PSA
to 4.5 ng/mL results in the failure to detect a substantial number
of clinically significant cancers.},
doi = {10.1016/S0090-4295(98)00366-5},
file = {BasslerJr1998.pdf:BasslerJr1998.pdf:PDF},
issn = {0090-4295},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.sciencedirect.com/science/article/B6VJW-3WDDGNS-X/2/7788fa7215b63cc1fa1231c164c641c6}
}
@article{Veltri1998,
author = {Veltri, R. W. and O'Dowd, G. J. and Orozco, R and Miller, M. C.},
title = {The role of biopsy pathology, quantitative nuclear morphometry, and
biomarkers in the preoperative prediction of prostate cancer staging
and prognosis.},
journal = {Semin Urol Oncol.},
year = {1998},
volume = {16},
pages = {106-117},
number = {3},
month = {Aug},
lu_pub_type = {a_article},
display_order = {1},
abstract = {The focus of this review is to survey pretreatment biopsy and patient-derived
information applicable to predicting pathological stage and prognosis
of men with a diagnosis of prostate cancer. Various sources of clinical
and pathological information that may contribute to building decision
support tools (DSTs) for application by the urologist to manage prostate
cancer patients are presented. These DSTs use serum biomarkers and
objective, well-established, pathology information extracted by experienced
pathologists from needle-core tissue samples that describe tumor
size, grade, and location. Other valuable data can be derived from
the biopsy tissue, such as computer-assisted image cytometry-derived
DNA ploidy and nuclear morphometry informatics, as well as select
tissue biomarker results that may provide supplemental prognostic
information. Also discussed are the technical and clinical limitations
of these DSTs with respect to the prediction accuracy. A commercially
available pretreatment prediction algorithm (UroScore, Oklahoma City,
OK) was applied to predict the disease organ confinement status of
the prostate cancer test case. Finally, the authors present existing
and future applications of computer-derived computational solutions
for incorporating all patient history, clinical laboratory, and pathology
information into algorithms that can generate patient-specific predictive
probability estimates of stage, recurrence, and progression.},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9741414}
}
@article{BasslerJr1999,
author = {T. J. {Bassler Jr} and R. Orozco and I. C. Bassler and L. M. Boyle
and T. Bormes},
title = {Adenosquamous carcinoma of the prostate: Case report with DNA analysis,
immunohistochemistry, and literature review},
journal = {Urology},
year = {1999},
volume = {53},
pages = {832 - 834},
number = {4},
month = {Apr.},
lu_pub_type = {a_article},
display_order = {1},
abstract = {We diagnosed prostatic adenosquamous carcinoma by prostate core needle
biopsy in a 55-year-old man with no history of prostate cancer. The
prognosis, DNA analysis, and histogenesis of this extremely rare
tumor are controversial. To our knowledge, this is the first case
of adenosquamous carcinoma diagnosed by core needle biopsy in a patient
with no history of prostate cancer or hormonal therapy. We performed
immunohistologic and DNA analysis to further characterize this cancer.
The clinical presentation and abnormal DNA analysis portend an aggressive
course.},
doi = {10.1016/S0090-4295(98)00418-X},
file = {BasslerJr1999.pdf:BasslerJr1999.pdf:PDF},
issn = {0090-4295},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.sciencedirect.com/science/article/B6VJW-3W48RVP-19/2/97130bce7f105a16fc18c31a2b6c241b}
}
@article{Wojcik1999,
author = {Wojcik, E. M. and {Bassler Jr}, T. J. and Orozco, R.},
title = {DNA ploidy in seminal vesicle cells. A potential diagnostic pitfall
in urine cytology.},
journal = {Anal Quant Cytol Histol.},
year = {1999},
volume = {21},
pages = {29-34},
number = {1},
month = {Feb.},
lu_pub_type = {a_article},
display_order = {1},
abstract = {OBJECTIVE: To verify that abnormal DNA ploidy in urine cytology can
occasionally be attributed to contamination by seminal vesicle cells.
STUDY DESIGN: In the first part of this study, we analyzed the DNA
content of six urine cytology specimens containing seminal vesicle
cells. In the second part, we evaluated 21 Feulgen-stained prostate
core biopsies containing seminal vesicle-type epithelium using a
CAS-200 system. DNA index, proliferative activity (S + G2M) and degree
of hyperploidy (> 5C) were determined in each case.
RESULTS: All six urine cytology specimens were diploid, with all but
one containing hyperploid cells (range, 0-16\%; mean, 6.3\%). Seminal
vesicle cells from prostate biopsies showed a broad range of ploidy
abnormalities. Ten cases (48\%) showed an aneuploid peak, two cases
(9\%) showed a tetraploid peak, and nine cases (43\%) showed only
a diploid peak. All but one case showed both an elevation in proliferative
activity (mean S + G2M, 24.2\%) and some hyperploid cells (mean,
> 5C; 4.5\%).
CONCLUSION: Seminal vesicle cells, although rarely seen in urine cytology,
can cause abnormal DNA ploidy measurements. Morphologic criteria
remain vital to an accurate cytologic diagnosis.},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10068772}
}
@article{ODowd2000,
author = {O'Dowd, Gerard J and Miller, M.Craig and Orozco, Roberto and Veltri,
Robert W},
title = {Analysis of repeated biopsy results within 1 year after a noncancer
diagnosis},
journal = {Urology},
year = {2000},
volume = {55},
pages = {553--558},
number = {4},
month = apr,
lu_pub_type = {a_article},
display_order = {1},
abstract = {Objectives. A prostate biopsy data base derived from patients referred
to private practice urologists was analyzed for the cancer diagnosis
rates of the “initial” biopsy and the repeated biopsy performed within
1 year for those patients with a noncancer diagnosis. Methods. A
retrospective analysis assessed 132,426 prostate biopsies received
and processed by a single pathology laboratory between March 1994
and September 1998; none had had a previous biopsy processed at this
laboratory. Prostate cancer was diagnosed in 50,521 of the patients
(38.2\%). The remaining 81,905 patients (61.8\%) had a noncancer
diagnosis of either no evidence of malignancy (NEM), high-grade prostatic
intraepithelial neoplasia (HGPIN), small acinar glands suspicious
for cancer (suspicious), or suspicious with HGPIN (Susp-HGPIN). We
identified 6380 (7.8\%) of these “noncancer” patients who underwent
a repeated biopsy within 1 year. Results. The incidence of NEM, HGPIN,
suspicious, and Susp-HGPIN biopsy diagnoses in the “noncancer” patients
(81,905) was 55.3\%, 3.7\%, 2.5\%, and 0.3\%, respectively. The rate
at which these “noncancer” patients (81,905) underwent a repeated
biopsy was 4.8\% for patients with a diagnosis of NEM, 26.6\% for
HGPIN, 40.4\% for suspicious, and 47.5\% for Susp-HGPIN. The overall
cancer diagnosis rate in the repeated biopsy patient sample (6380)
was 25.7\%. When stratified by the initial biopsy diagnosis, the
cancer diagnosis rate for the repeated biopsies was 19.8\%, 22.6\%,
40.0\%, and 53.1\%, for the patients with NEM, HGPIN, suspicious,
and Susp-HGPIN, respectively. The repeated biopsy diagnosis rates
did not vary dramatically when analyzed at 3-month intervals during
the 1-year period. Also, a strong correlation (79\%) was observed
between the number of tissue samples obtained at the initial and
repeated biopsy procedures. In a subset of patients with free and
total prostate-specific antigen (PSA) results obtained before the
repeated biopsy (n = 813), we were able to construct a multivariate
logistic regression algorithm using the patients’ age, initial biopsy
diagnosis, total PSA, and free/total PSA ratio that could predict
the likelihood of cancer on the repeated biopsy with an accuracy
of 70\%. Conclusions. Men who have an initial noncancerous biopsy
diagnosis remain at risk of prostate cancer, especially if the initial
diagnosis was suspicious or Susp-HGPIN. These data suggest that the
initial biopsy strategy needs to be improved and/or expanded to increase
the overall cancer detection rate in the primary biopsy. In addition,
combining factors such as the initial biopsy diagnosis, family history,
digital rectal examination results, prostate gland volume, age, total
PSA, and free/total PSA ratio could provide valuable information
for predicting the likelihood of cancer.},
file = {ODowd2000.pdf:ODowd2000.pdf:PDF},
issn = {0090-4295},
owner = {UsuariO},
publisher = {Elsevier Science},
refid = {S0090-4295(00)00447-7},
timestamp = {2010.10.02},
url = {http://linkinghub.elsevier.com/retrieve/pii/S0090429500004477?showall=true}
}
@article{Saravia-Flores2009,
author = {Marcos Saravia-Flores and Ana Eugenia Ponciano and Víctor Leonel
Argueta and Roberto Orozco},
title = {Adenosis esclerosante extensa de la pr\'{o}stata},
journal = {Patolog\'{i}a},
year = {2009},
volume = {47},
pages = {125-127},
number = {2},
month = {Abr.-Jun.},
lu_pub_type = {a_article},
display_order = {1},
eprint = {http://www.nietoeditores.com.mx/download/patologia/abril-junio2009/Patologia%202.10%20ADENOSIS.pdf},
abstract = {RESUMEN
La adenosis esclerosante de la próstata es una lesión poco frecuente
que se distingue por la proliferación de glándulas de tamaño variable,
células basales con diferenciación mioepitelial y células fusiformes
estromales. Esta lesión puede confundirse con adenocarcinoma por
su patrón arquitectural y porque muestra atipia nuclear y nucléolos.
Casi siempre se manifiesta como un nódulo único confinado a la zona
de transición. Se comunica un caso de adenosis esclerosante extensa
de la próstata en un paciente de 77 años de edad que afectaba
aproximadamente 50\% del tejido prostático examinado.
ABSTRACT
Sclerosing adenosis of the prostate is an infrequent lesion histologically
characterized by a glandular proliferation with basal cells showing
mioepithelial differentiation admixed in cellular spindle cell stroma.
Sclerosing adenosis can be misdiagnosed as adenocarcinoma, especially
when nuclear atypia and prominent nucleoli are present. The majority
of the cases have single nodules confined to the transition
zone. We present the case of an extensive sclerosing adenosis of prostate
in a 77 years old male patient, affecting approximately 50\%
of the prostatic volume.},
file = {Saravia-Flores2009.pdf:Saravia-Flores2009.pdf:PDF},
keywords = {próstata, adenosis esclerosante. / prostate, sclerosing adenosis.},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.nietoeditores.com.mx/vol-47-num-2-abril-junio-2009/1524-adenosis-esclerosante-extensa-de-la-prostata.html}
}
@article{SaraviaFlores2009b,
author = {{Saravia Flores}, Marcos Rodrigo and Argueta, Victor Leonel and {Morales
Ruiz}, Mario Roberto and {Orozco Florian}, Roberto Elfidio},
title = {Mucinous cystadenocarcinoma of the renal pelvis: a case report and
clues to histogenesis},
journal = {BMJ Case Reports},
year = {2009},
volume = {2009},
month = {Feb.},
lu_pub_type = {a_article},
display_order = {1},
abstract = {We present a case of mucinous cystadenocarcinoma of the renal pelvis
associated with a collecting duct carcinoma in a 58-year-old woman
with diabetes. Even though several theories about the aetiology of
mucinous cystadenocarcinoma of the renal pelvis have been proposed,
its origin remains unknown. The present case shows a distinct morphology
and immunohistochemical profile that may suggest a clue to its histogenesis.},
doi = {10.1136/bcr.06.2008.0307},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://casereports.bmj.com/content/2009/bcr.06.2008.0307.abstract}
}
@article{SaraviaFlores2009a,
author = {{Saravia Flores}, Marcos Rodrigo and {Morales Ruiz}, Mario Roberto
and {Orozco Florian}, Roberto Elfidio and De Leon, Werner and {San
Jose}, Luis},
title = {Pan-urothelial verrucous carcinoma unrelated to schistosomiasis},
journal = {BMJ Case Reports},
year = {2009},
volume = {2009},
month = {Apr.},
lu_pub_type = {a_article},
display_order = {1},
abstract = {Verrucous carcinoma is a well differentiated squamous cell carcinoma
with a well known histological appearance and clinical behaviour.
We present a case of verrucous carcinoma extensively affecting the
urothelium of the right renal pelvis, right ureter and urinary bladder
over a 3-year period. This pan-urothelial involvement of a verrucous
carcinoma has not been previously reported. The potential for regional
spread with subsequent urinary tract obstruction by this tumour calls
for aggressive local surgical treatment as the main modality of therapy.},
doi = {10.1136/bcr.08.2008.0787},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://casereports.bmj.com/content/2009/bcr.08.2008.0787.abstract}
}
@article{ArevaloPortillo2010,
author = {Ar\'{e}valo Portillo, Estela Nelhs and Argueta Sandoval, Victor and
Orozco, Roberto and Mena Aplicano, Ricardo},
title = {Hallazgos en necropsias realizadas a pacientes diagnosticados con
influenza A (H1N1)},
journal = {Revista Espa\~{n}ola de Patolog\'{i}a},
year = {2010},
volume = {43},
pages = {187 - 190},
number = {4},
month = {Oct.-Dec.},
lu_pub_type = {a_article},
display_order = {1},
abstract = {RESUMEN Antecedentes En 2009 la OMS declaró la influenza A (H1N1)
como la primera pandemia del siglo xxi. Guatemala reportó 1.032 casos
confirmados y 18 muertes. A cinco de estos casos se les realizó necropsia
en el Hospital General San Juan de Dios (HGSJD).Casos clínicos Los
casos eran cuatro pacientes adultos y un paciente pediátrico; tres
de sexo masculino y dos de sexo femenino. Todos los casos fueron
tratados como neumonía y fueron referidos al HGSJD, no respondieron
al tratamiento y murieron. Un caso presentó alteración del estado
de conciencia.Resultados Los hallazgos más importantes de las necropsias
fueron: daño alveolar difuso en cuatro pacientes, en uno de estos
se encontró infarto hemorrágico cerebral y en el quinto caso pancreatitis
hemorrágica, que fue la paciente pediátrica.Conclusiones El hallazgo
postmortem común y más relevante en cuatro de los pacientes, fue
daño alveolar difuso; sin embargo, hallazgos como la pancreatitis
hemorrágica y el infarto hemorrágico cerebral, deben ser tomados
en cuenta en evaluaciones posteriores de casos positivos.
ABSTRACT Background According to the WHO, the first pandemic of the
xxi century was caused by influenza A (H1N1). 1032 cases were confirmed
in Guatemala, 18 cases of which resulted in death. Five of these
patients underwent an autopsy at the Hospital General San Juan de
Dios (HGSJD)Clinical cases Autopsies were performed on four adults
and one child. All patients had been treated for pneumonia before
being referred to the HGSJD. However, they did not respond to treatment
and died. Alterations to the level of consciousness were seen in
one case.Results In four of the five patients, diffuse alveolar damage
was the main pathological feature. Other relevant findings were a
cerebral haemorrhagic infarct in one patient and haemorrhagic pancreatitis
in the paediatric patient.Conclusions Although diffuse alveolar damage
was the main finding on autopsy, haemorrhagic pancreatitis and cerebral
haemorrhagic infarct were also found and should be considered in
future studies on influenza A (H1N1).},
doi = {10.1016/j.patol.2010.07.001},
file = {ArevaloPortillo2010.pdf:ArevaloPortillo2010.pdf:PDF},
issn = {1699-8855},
keywords = {Influenza A (H1N1), Daño alveolar difuso; Neumonía / Influenza A (H1N1);
Diffuse alveolar damage; Pneumonia},
owner = {U},
timestamp = {2010.12.03},
url = {http://www.elsevier.es/revistas/ctl_servlet?_f=7012&articuloid=13188645&revistaid=297}
}
@article{GuerraLopez2012,
author = {Beatriz Lorelai {Guerra López} and Estuardo Enrique {Lemus Gonzalez}
and Jenifer Margoth {Rodriguez López} and Juan Francisco {Reyes Mendez}
and Marco Polo {López Tot} and María Fernanda {García García} and
Mario Roberto {Estrada Cifuentes} and Ross Mari {Valdez Anleu} and
Julian Alejandro {Saquimux Canastuj} and Roberto Orozco and Victor
Leonel Argueta and Miguel Garcés and Helen Morales},
title = {Prevalencia de Cáncer en los Órganos de los Pacientes Diagnosticados
en el Departamento de Patología Dr. Carlos Martínez Durán del Hospital
General San Juan de Dios, y Tres Laboratorios Privados de Patología.
Ciudad de Guatemala, Período 2,006 al 2,010.},
journal = {Revista del Colegio de Medicos y Cirujanos de Guatemala},
year = {2012},
volume = {2},
pages = {5 - 15},
number = {1},
lu_pub_type = {a_article},
display_order = {1},
eprint = {http://www.colmedegua.org/download/212/},
abstract = {Objetivo:
Determinar la prevalencia de los órganos afectados por cáncer diagnosticados
en el Departamento de Patología Dr. Carlos Martínez Duran del Hospital
General San Juan de Dios, Laboratorio de Patología Dr. Víctor Argueta,
Laboratorio de Patología Dr. Roberto Orozco y Laboratorio de Patología
y Citología Dr. Miguel Garcés y Dra. Helen Morales, ubicados en la
Ciudad de Guatemala, años 2,006 - 2,010.
Metodología:
La investigación está regida por un estudio cuantitativo, descriptivo,
no experimental, retrospectivo, realizado en 3 laboratorios privados
de patología de la ciudad de Guatemala y en el Departamento de Patología
Dr. Carlos Martínez Durán del Hospital General San Juan de Dios,
1 de enero del año 2006 al 31 de diciembre del año 2010.
Se revisaron 108,764 quirúrgicas, de niños, niñas, hombres y mujeres
a los que se les analizó una biopsia o pieza resecada en los cuatros
laboratorios de patología que forman parte del estudio, de esta 4,736
comprenden órganos con cáncer equivalente a 4.35%. Estos informes
fueron analizados con el propósito de identificar la prevalencia
de cáncer en los órganos de los pacientes diagnosticados en estos
laboratorios. Se utilizó Microsoft Access para la realización del
instrumento de tabulación en el cual se recolecto información necesaria,
como el órgano afectado por cáncer en cada paciente, la edad y sexo.
Para la realización del estudio se contó con la autorización del Jefe
del Departamento de Patología Dr. Carlos Martínez Duran del Hospital
General San Juan de Dios y de los propietarios de los laboratorios
privados, y se aseguró la confiabilidad de la información de cada
paciente.
Resultados:
La suma de resultados de los cuatro laboratorios mostró un total de
4,736 casos de órganos con cáncer en ambos sexos. Los principales
órganos afectados con cáncer son: la próstata (15.24%), piel (13.49%),
cuello uterino (13.26%), mama (8.91%) y estómago (8.17%).
En la población femenina se registraron 2,572 órganos con cáncer;
los más afectados son: el cuello uterino (24.42%), mama (16.42%),
piel (10.97%), estómago (7.16%), colon y recto (5.37%) y cuerpo uterino
(5.25%).
En la población masculina se registraron 2,164 órganos con cáncer;
los más afectados son: la próstata (33.36%), piel (16.50%), estómago
(9.38%), ganglio linfático (5.96%), vejiga (5.13%) y colon y recto
(4.76%).
Al comparar los resultados de los laboratorios privados con el Departamento
de Patología Dr. Carlos Martínez Durán del Hospital General San Juan
de Dios en ambos sexos, muestran diferencias, en los laboratorios
privados los órganos más afectados con cáncer son próstata (20.70%),
piel (17.85%), cuello uterino (13.50%), estómago (8.06%) y mama (7.50%),
y en el Departamento de Patología del Hospital San General San Juan
de Dios son: cuello uterino (12.95%), mama (10.73%), ganglio linfático
(8.89%), estómago (8.31%) y próstata (8.22%).
Al comparar el sector privado y el sector público, en sexo femenino,
se observa que en ambos sectores el cuello uterino se encuentra en
primer lugar 26.95% y 21.68% respectivamente. El sexo masculino en
ambos sectores se encuentra próstata como primer lugar 41.47% y 20.41
respectivamente y piel como segundo 19.46% y 11.76 respectivamente.
Conclusión:
Los estudios similares de GLOBOCAN e INCAN en su mayoría, no coinciden;
aunque es importante resaltar que para GLOBOCAN y en el presente
estudio realizado en los 4 laboratorios se encuentra como órgano
más afectado con cáncer en ambos sexos la próstata, según INCÁN el
órgano más prevalente es el cuello uterino.
En este estudio, el cuello uterino es el órgano más afectado con cáncer
en el sexo femenino y coincide con lo publicado en GLOBOCAN e INCAN.
El órgano más afectado en sexo masculino es la próstata en el presente
estudio y coincide con los reportes de GLOBOCAN, a diferencia de
INCAN, que reporta estómago con mayor prevalencia.
Se encontró que los grupos donde se encuentra la mayor cantidad de
personas afectadas, se inicia a partir de la cuarta década de la
vida, lo cual corresponde al desarrollo fisiopatológico del cáncer;
así como también fue encontrado que el sexo femenino es el más afectado
por cáncer 54.29%, en comparación con el sexo masculino 45.71% en
los 4 laboratorios de Patología.},
file = {GuerraLopez2012.pdf:GuerraLopez2012.pdf:PDF},
keywords = {Órgano, cáncer, prevalencia, sexo y edad.},
owner = {U},
timestamp = {2013.07.14},
url = {http://www.colmedegua.org/download/212/}
}
@article{Lopez2013,
author = {Lopez, J.I. and Guarch, R. and Larrinaga, G. and Corominas-Cishek,
A. and Orozco, R.},
title = {Cell heterogeneity in clear cell renal cell carcinoma},
journal = {APMIS},
year = {2013},
volume = {Epub ahead of print},
month = {Mar. 20},
lu_pub_type = {a_article},
display_order = {1},
abstract = {The aim of this study was to define the histological spectrum, frequency
and significance of nonconventional tumour cells in clear cell renal
cell carcinomas (CCRCC). Fifty-one totally sampled CCRCC were studied
histologically to evaluate the spectrum of cell morphology variability,
its frequency and significance, and their correlation with tumour
grade and stage, and other histological parameters of aggressive
behaviour like necrosis. Aside from conventional clear/eosinophilic
granular cells, three additional cellular types were identified and
considered in this study: small clear cells, syncytial cells and
rhabdoid cells. Small clear cells were detected in 11 cases (21.5%),
syncytial cells in 8 (15.6%) and rhabdoid cells in 5 (9.8%). The
presence of syncytial and rhabdoid cells statistically correlated
with grade (p = 0.003 and p = 0.006) and stage (p = 0.049 and p =
0.05) in CCRCC. Necrosis correlated with stage (p = 0.018) and grade
(p = 0.004), but not with syncytial, rhabdoid or small clear cells.
The presence of syncytial and rhabdoid cells in CCRCC is a relatively
frequent event that significantly correlates with high-grade tumours
and high stage status.},
doi = {10.1111/apm.12073},
owner = {U},
timestamp = {2013.07.14}
}
@article{Rafuse1992,
author = {Rafuse, V. F. and Gordon, T. and Orozco, R.},
title = {Proportional enlargement of motor units after partial denervation
of cat triceps surae muscles},
journal = {J Neurophysiol},
year = {1992},
volume = {68},
pages = {1261--1276},
number = {4},
month = oct,
lu_pub_type = {a_article},
display_order = {2},
abstract = {1. To determine the capacity of motoneurons to increase their motor
unit (MU) size by collateral sprouting and to assess this capacity
in relation to the size of the motor nerve, we partially denervated
soleus, lateral gastrocnemius (LG), and medial gastrocnemius (MG)
muscles in adult and neonatal cats. Isometric force and extracellular
nerve potentials were recorded from > or = 7\% of the remaining MUs,
2.5-18 mo later. S1 or L7 roots were sectioned unilaterally and the
number of remaining MUs was quantified by use of charge and force
measurements. 2. The mean unit force increased inversely with MU
number in partially denervated muscles, but the increase was less
than predicted for extensive denervations (> or = 90\%). The same
enlargement of MU size occurred whether muscles were partially denervated
in neonatal or adult animals. 3. The force distribution of MUs in
partially denervated muscles was similar to normal but was shifted
to larger force values in direct proportion to the extent of partial
denervation (PD). All MUs increased in size by the same factor to
preserve the normal force distribution. 4. Normal size relationships
among force, contractile speed, and axon potential amplitude were
observed for MUs in partially denervated muscles. Because changes
in muscle fiber size could not account for the increase in unit force,
these data show that increase in MU size, with respect to unit force
and innervation ratio (muscle fibers per motoneuron), is proportional
to the size of the motor nerve. 5. Enlargement of MU size in partially
denervated muscles did not have a retrograde effect on nerve fiber
caliber because axon potential amplitude and conduction velocity
were not changed after PD. 6. Under conditions of extensive PD (>
85\%), regenerated nerves from the cut spinal root reinnervated the
gastrocnemius muscles. It is likely that nerves supplied muscle fibers
that were not innervated by sprouts from nerves in the uncut root
as well as displacing sprouts from terminals in extensively enlarged
MUs. 7. We conclude that all motoneurons within a motor pool compensate
for partial nerve injuries by collateral sprouting and that enlargement
of MU size is a function of motor nerve size, consistent with Henneman's
size principle.},
file = {Rafuse1992.pdf:Rafuse1992.pdf:PDF},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://jn.physiology.org/cgi/content/abstract/68/4/1261}
}
@article{Orozco1989,
author = {Orozco, R and Tran, H. T. and Stiles, G},
title = {Ileal intussusception due to an inflammatory fibroid polyp mimicking
an intestinal lymphoma},
journal = {Sci Med Bull},
year = {1989},
volume = {10},
pages = {13-16},
number = {1},
lu_pub_type = {a_article},
display_order = {3},
owner = {U},
timestamp = {2010.11.13}
}
@article{Gordon1991,
author = {Gordon, T and Gillespie, J and Orozco, R and Davis, L},
title = {Axotomy-induced changes in rabbit hindlimb nerves and the effects
of chronic electrical stimulation},
journal = {J. Neurosci.},
year = {1991},
volume = {11},
pages = {2157-2169},
number = {7},
lu_pub_type = {a_article},
display_order = {3},
eprint = {http://www.jneurosci.org/cgi/reprint/11/7/2157.pdf},
abstract = {Chronic electrical stimulation and extracellular recording combined
with morphological examination of nerves in this study provided a
detailed description of the time course and extent of fiber atrophy
when the trophic influence of the target was removed by ligation
of axotomized nerves and neural activity was replaced by chronic
stimulation. The major findings are that decline in amplitude of
compound action potentials (CAPs) and fiber diameters is rapid after
axotomy and is not reversed or prevented by chronic electrical stimulation,
as would be predicted if neural activity played an essential role
in maintaining normal fiber caliber. Chronic stimulation had a small
short-term sparing effect in the first month after axotomy but was
counterproductive over long periods. Comparison of the time course
of the decline in CAP amplitude and reduction of fiber diameters
with described alterations in mRNA expression of neurofilament protein
indicates that the early atrophy is too rapid to be accounted for
by reduced synthesis and transport of neurofilaments. It is more
likely to result from modification of axonal proteins after axotomy.
Replacement of neural activity with stimulation may reduce the initial
atrophy but, over longer periods, exacerbates the atrophy, possibly
by affecting the synthesis and transport of cytoskeletal proteins.
These studies show that the trophic control of nerve fiber size is
mediated primarily by functional contacts with peripheral targets
and that neural activity plays a relatively small role. Without functional
contacts, nerve fibers decline in diameter to stable but lower values.
The atrophy was exacerbated by imposing neural activity on the relatively
quiescent axotomized neurons.},
file = {Gordon1991.pdf:Gordon1991.pdf:PDF},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.jneurosci.org/cgi/content/abstract/11/7/2157}
}
@article{Orozco-Florian1991a,
author = {Orozco-Florian, R and Trillo, A},
title = {Identification of Pneumocystis carinii by quick hematoxylin and eosin
smear},
journal = {J Histotech},
year = {1991},
volume = {14},
pages = {179-180},
number = {3},
month = {Sep.},
lu_pub_type = {a_article},
display_order = {3},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco-Florian1991a.pdf},
file = {Orozco-Florian1991a.pdf:Orozco-Florian1991a.pdf:PDF},
owner = {U},
timestamp = {2010.11.15},
url = {http://www.nsh.org/content/archives}
}
@article{Orozco-Florian1991,
author = {Orozco-Florian, Roberto and McBride, J. Adelia and Favara, Blaise
E. and Steele, Ann and Brown, John and Steele, Peter},
title = {Congenital hepatoblastoma and Beckwith-Wiedemann syndrome: a case
study including DNA ploidy profiles of tumor and adrenal cytomegaly},
journal = {Fetal \& Pediatric Pathology},
year = {1991},
volume = {11},
pages = {131-142},
number = {1},
lu_pub_type = {a_article},
display_order = {3},
abstract = {A case of fatal congenital hepatoblastoma is described in which the
autopsy provided the first evidence of Beckwith-Wiedemann syndrome.
Aneuploid quantitative DNA patterns were found by image analysis
of the tumor and the cytomegalic adrenal gland.},
doi = {10.3109/15513819109064749},
file = {Orozco-Florian1991.pdf:Orozco-Florian1991.pdf:PDF},
keywords = {adrenal cytomegaly, aneuploidy, Beckwith-Weidemann syndrome, DNA ploidy,
hepatoblastoma},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://informahealthcare.com/doi/abs/10.3109/15513819109064749}
}
@article{Raza-Ahmad1991,
author = {Raza-Ahmad, A and Orozco-Florian, R},
title = {Pathology of valvular heart disease in adults in Nova Scotia: Analysis
of surgically removed valves},
journal = {The Nova Scotia Medical Journal},
year = {1991},
volume = {70},
pages = {71-73},
month = {Jun.},
lu_pub_type = {a_article},
display_order = {3},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Raza-Ahmad1991.pdf},
file = {Raza-Ahmad1991.pdf:Raza-Ahmad1991.pdf:PDF},
owner = {U},
timestamp = {2010.11.14}
}
@article{Orozco2007,
author = {Roberto E Orozco and Víctor Leonel {Argueta F} and Marcos R {Saravia
Flores}},
title = {P\'{o}lipos fibroepiteliales estromales del cuello uterino},
journal = {Patolog\'{i}a},
year = {2007},
volume = {45},
pages = {165-168},
number = {4},
month = {Oct.-Dec.},
lu_pub_type = {a_article},
display_order = {3},
eprint = {http://nietoeditores.com.mx/download/patologia/octubre-diciembre2007/Pat%20165-8.pdf},
abstract = {RESUMEN
Los pólipos fibroepiteliales estromales atípicos son lesiones benignas
de origen desconocido. Su apariencia histológica es variada, pero
su curso clínico es benigno. Pueden tener características celulares
atípicas, mitosis o estroma hipercelular, lo que puede llevar a sobrediagnosticarlos
como sarcomas. El objetivo de este artículo es informar dos casos
de pólipos fibroepiteliales estromales atípicos. Se trata de dos
mujeres, de 40 y 80 años de edad, quienes tuvieron diversos síntomas
y signos en el aparato genital bajo, con grandes masas polipoides
en el cuello uterino que se interpretaron, inicialmente, como lesiones
malignas. Se informan los hallazgos histológicos y se discuten las
dificultades diagnósticas que ofrecen estas lesiones. Ambos casos
se resolvieron quirúrgicamente, sin recurrencias. Estas neoplasias
deben diferenciarse correctamente, para no confundirlas con lesiones
malignas.
ABSTRACT
Atypical fibroepithelial stromal polyps (AFESP) are benign lesions
of unknown etiology. The histological appearances of these polyps
are protean, but their clinical course is benign. These lesions can
exhibit bizarre cytomorphology, atypical mitoses, or hypercellular
stroma, mimicking malignant tumors. The aim of this article is to
inform the clinicopathological findings of two cases of AFESP of
the uterine cervix; the diagnostic problems of those lesions are
also discussed. The cases were two women aged 40 and 80 years. Both
cases were surgically solved and the tumors have not recurred. These
tumors should be correctly identified, in order to avoid confusing
them with malignant lesions},
file = {Orozco2007.pdf:Orozco2007.pdf:PDF},
keywords = {cuello uterino, pólipos, lesiones estromales. / uterine cervix, polyps,
malignant lesions.},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://nietoeditores.com.mx/volumen-45-num-4-octubre-diciembre-2007/338-polipos-fibroepiteliales-estromales-del-cuello-uterino.html}
}
@book{Gordon1988,
title = {Comparison of Injury and Development in the Neuromuscular System},
publisher = {John Wiley \& Sons, Ltd.},
year = {1988},
author = {Gordon, T. and Bambrick, L. and Orozco, R.},
pages = {210 - 226},
lu_pub_type = {b_book_chapter},
abstract = {Summary : Comparisons of development and regeneration have suggested
that axotomized motoneurons and denervated muscles undergo dedifferentiation
to an embryonic state with recovery of adult properties after reinnervation.
Using electrophysiological and radioligand-binding techniques to
monitor axonal size and numbers of extrajunctional acetylcholine
receptors in axotomized motoneurons and denervated muscles respectively,
we have demonstrated that this dedifferentiation is limited. We suggest
that this limited dedifferentiation may be adaptive for survival,
regeneration and reinnervation. Correlative physiological and histochemical
studies of reinnervated motor units in cat and rat hindlimb muscles
show that the processes of regeneration and reinnervation differ
in a number of fundamental ways from developmental processes of axonal
growth and muscle innervation. Enlargement of motor units after partial
nerve injuries does not appear to be limited to the size of the neonatal
motor unit as originally suggested but may be influenced by factors
operating at the level of axonal branching. Regeneration after complete
and partial nerve injuries is a random process in contrast to the
specific nature of the innervation of targets during development.
Regenerating axons frequently fail to make connections with their
original muscles and newly reinnervated motor units contain muscle
fibres which formerly belonged to several different motor units.
Despite this misdirection of regenerating nerve fibres, neuromuscular
plasticity restores neuromuscular properties to the extent that these
are appropriate at the single motor unit level for the gradation
of force by the orderly recruitment of units during movement.},
booktitle = {Ciba Foundation Symposium 138 - Plasticity of the Neuromuscular System},
doi = {10.1002/9780470513675.ch13},
issn = {9780470513675},
keywords = {neuromuscular system, axonal branching, neuromuscular plasticity,
nerve fibres, axonal growth},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://dx.doi.org/10.1002/9780470513675.ch13}
}
@inproceedings{Orozco1984,
author = {Orozco, Roberto and Gordon, Tessa},
title = {Compensation for partial peripheral nerve injuries},
booktitle = {The First Neuroscience Meeting, University of Alberta},
year = {1984},
address = {Alberta, CA},
lu_pub_type = {c_abstract},
lu_note = {check (conference title ok, month)},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1984.pdf},
file = {Orozco1984.pdf:Orozco1984.pdf:PDF},
owner = {U},
timestamp = {2010.12.03}
}
@article{Orozco1985,
author = {Orozco, R and Gordon, T and Davis, L.A. and Goldsand, G},
title = {Chronic electrical stimulation of axotomized neurons in the rabbit},
journal = {Soc Neurosci Abstr},
year = {1985},
volume = {11},
pages = {1146},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1985.pdf},
file = {Orozco1985.pdf:Orozco1985.pdf:PDF},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{Orozco1986,
author = {Orozco, R and Gordon, T},
title = {Response of medial gastrocnemius motor units to partial denervation},
year = {1986},
note = {Alberta Heritage Foundation for Medical Research},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1986.pdf},
file = {Orozco1986.pdf:Orozco1986.pdf:PDF},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{Gordon1987,
author = {Gordon, T and Orozco, R},
title = {Complete compensation for partial peripheral nerve injuries},
booktitle = {Abstracts of the IBRO Second World Congress of Neuroscience},
year = {1987},
volume = {22 suppl},
pages = {649},
address = {Budapest, Hungary},
month = {Aug.},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.16}
}
@article{Gordon1987a,
author = {Gordon, T. and Orozco, R.},
title = {Organization of motor unit properties in the cat triceps surae muscles
after partial denervation},
journal = {Soc Neurosci Abstr},
year = {1987},
volume = {13},
pages = {244},
note = {Presented at the Annual Neuroscience Meeting, Dallas, TX, USA, 1987.},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.16}
}
@article{MacLean1989,
author = {MacLean, G and Orozco-Florian, R and Sangalang, V},
title = {Malignant intravascular lymphoma: Immunochemical markers in 3 cases},
journal = {Can J Neurol Sci},
year = {1989},
volume = {16},
pages = {261 (Abstr. No. 30)},
number = {2},
month = {May},
note = {Presented at the XXIV Canadian Congress of Neurological Sciences,
Ottawa, Canada, Jun. 14-16 1989},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/MacLean1989.pdf},
file = {MacLean1989.pdf:MacLean1989.pdf:PDF},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{Orozco-Florian1990,
author = {Orozco-Florian, R and Trillo, A},
title = {Touch preparation detection (identification) of pneumocystis carinii},
booktitle = {Canadian Congress Laboratory Medical Abstracts},
year = {1990},
pages = {103},
address = {Saint John's, Newfoundland},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco-Florian1990.pdf},
file = {Orozco-Florian1990.pdf:Orozco-Florian1990.pdf:PDF},
owner = {U},
timestamp = {2010.11.16}
}
@article{Rafuse1990,
author = {Rafuse, V.F. and Gordon, T and Orozco, R and Gillespie, M.J.},
title = {Patterns of motoneuron sprouting in the cat triceps surae muscles},
journal = {Soc Neurosci Abstr},
year = {1990},
volume = {16},
pages = {52},
number = {7},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{Orozco1991,
author = {Orozco, R and Trillo, A},
title = {Glomerular abnormalities in sarcoidosis},
booktitle = {Can Con Lab Med and XVI World Congress of Anatomic and Clinical Pathology},
year = {1991},
pages = {6 (Abstr. No. 31)},
address = {Vancouver, BC, Canada},
month = {Jun. 22-27},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1991.pdf},
file = {Orozco1991.pdf:Orozco1991.pdf:PDF},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{Foust1993,
author = {Foust, Rebecca and Orozco, Roberto E. and Dockter, Michael E. and
Hermann-Petrin, Jeanne M. and Martin, Cynthia R. and Murphy, William
M.},
title = {Flow cytometry in clinical stage A prostate carcinoma},
booktitle = {82nd Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1993},
address = {New Orleans, LA},
month = {Mar. 13-19},
lu_pub_type = {c_abstract},
lu_note = {check},
owner = {U},
timestamp = {2010.12.02}
}
@article{Orozco1993b,
author = {Orozco, R and Foust, R and Dockter, M.E. and Hermann-Petrin, J.M.
and Martin, C.R. and Murphy, W.M.},
title = {Flow cytometry (FCM) of transurethral resections (TURPs) from prostates
with stage A cancer},
journal = {Mod Pathol Abstr},
year = {1993},
volume = {6},
pages = {65A (Abstr. No. 370)},
note = {Presented at the 82nd Annual Meeting of the United States and Canadian
Academy of Pathology, New Orleans, LA, Mar. 13-19, 1993},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1993b.pdf},
file = {Orozco1993b.pdf:Orozco1993b.pdf:PDF},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{Orozco1994a,
author = {Orozco, R.},
title = {Histopathological changes seen after cryoablation of the prostate},
booktitle = {Second Annual Prostate Cryosurgery Users Conference},
year = {1994},
address = {Dallas, TX},
month = {Oct. 7-8},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.16}
}
@article{Wright1994,
author = {Wright, G.L and Beckett, M.Z. and Haley, C and Huang, C.L. and Schellhammer,
P.F. and Veltri, R.W. and Patton, D.P. and Singer, D.P. and Marley,
G.M. and Orozco, R.E.},
title = {BP52: A biomarker of benign prostate hyperplasia},
journal = {J Urol},
year = {1994},
volume = {151},
pages = {297A},
note = {Presented at the American Urological Association Annual Meeting,
San Francisco, CA, May 1994},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Wright1994.pdf},
file = {Wright1994.pdf:Wright1994.pdf:PDF},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{ODowd1995,
author = {O'Dowd, GJ and Marley, G and Bacus, M and Orozco, R and Durand, D
and Veltri, R.},
title = {Evaluation of DNA content and chromatin complexity as stratification
parameters to assess severe urothelial atypias in urinary cytology
specimens obtained in a pathology reference laboratory},
booktitle = {Ninetieth Annual Meeting of the American Urological Association (AUA)},
year = {1995},
pages = {456A},
address = {Las Vegas, NV},
month = {Apr. 23-28},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/ODowd1995.pdf},
file = {ODowd1995.pdf:ODowd1995.pdf:PDF},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Orozco1995a,
author = {Orozco, Roberto and O'Dowd, Gerard and Rao, Vasantha},
title = {Histopathological changes of the prostate following cryoablation},
booktitle = {Ninetieth Annual Meeting of the American Urological Association (AUA)},
year = {1995},
address = {Las Vegas, NV},
month = {Apr. 23-28},
lu_pub_type = {c_abstract},
lu_note = {check},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1995a.pdf},
file = {Orozco1995a.pdf:Orozco1995a.pdf:PDF},
owner = {U},
timestamp = {2010.12.03}
}
@article{Bassler1996,
author = {Bassler, T.J. and Orozco, R.E. and Poole, E.C. and Wojcik, E.M. and
O'Dowd, G.J.},
title = {Seminal vesicle cells: Another cause of abnormal DNA ploidy in urine},
journal = {Acta Cytol},
year = {1996},
volume = {40},
pages = {1060 (Abstr. No. 61)},
note = {Presented at the 44th Annual Scientific meeting of the American Society
of Cytopathology, Denver, Colorado, Nov. 5-9, 1996},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{ODowd,
author = {O'Dowd, G. J. and Vasa, U. and Orozco, R. and Wojcik, E. M. and Miller,
M. C. and Veltri, W. R.},
title = {The diagnostic value of a combined feulgen DNA-M344 stain in urinary
cytology - a prospective blinded trial involving a urologic pathology
specialty laboratory},
booktitle = {91st Annual Meeting of the American Urological Association (AUA)},
year = {1996},
address = {Orlando, FL},
month = {May 4-9},
lu_pub_type = {c_abstract},
lu_note = {check},
owner = {U},
timestamp = {2010.12.03}
}
@article{Orozco1996a,
author = {Orozco, R and Marley, G and O'Dowd, G and Veltri, R},
title = {Free/total PSA ratio identifies men who have lower probabilities
of having a concurrent positive prostate biopsy},
journal = {Pathology International},
year = {1996},
volume = {46},
pages = {Abstr. No. 840},
number = {Suppl.},
note = {Presented at the XXI International Congress of the International
Academy of Pathology and 12th World Congress of Academic and Environmental
Pathology, Budapest, Hungary, Oct. 20-25,1996},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1996a.pdf},
file = {Orozco1996a.pdf:Orozco1996a.pdf:PDF},
owner = {U},
timestamp = {2010.11.17}
}
@article{Orozco1996,
author = {Orozco, R and Osobov, S and Bacus, M},
title = {Imaging and quantitation in surgical pathology},
journal = {Anal Quant Cytol Histol.},
year = {1996},
volume = {18},
pages = {Abstr. No. 89.},
number = {1},
note = {Presented at the Fourth International Conference on the Computerized
Cytology and Histology Laboratory, Chicago, Ilinois, Mar. 1996},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{Osobov1996,
author = {Osobov, Sergei and Orozco, Roberto and Bacus, Michael},
title = {Imaging and quantitation of prostate biopsies after cryosurgery},
booktitle = {91st Annual Meeting of the American Urological Association (AUA)},
year = {1996},
address = {Orlando, FL},
month = {May 4-9},
lu_pub_type = {c_abstract},
lu_note = {check},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Osobov1996.pdf},
file = {Osobov1996.pdf:Osobov1996.pdf:PDF},
owner = {U},
timestamp = {2010.12.03}
}
@article{Wojcik1996,
author = {Wojcik, E.M. Orozco, R and O'Dowd, G},
title = {Fine needle aspiration of prostate-comparison with follow-up core
biopsies},
journal = {Acta Cytol},
year = {1996},
volume = {40},
pages = {1095 (Abstr. No. 131)},
note = {Presented at the 44th Annual Scientific Meeting of the American Society
of Cytopathology, Denver, Colorado, Nov. 5-9, 1996},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@article{Bassler1997,
author = {Bassler, T and Orozco, R.E. and Poole, E.C. and O'Dowd, G},
title = {Histologic features of transitional cell carcinoma in prostatic core
biopsies},
journal = {Am J Clin Pathol},
year = {1997},
pages = {477 (Abstr. No. 37)},
note = {Presented at the Spring Meeting of the American Society of Clinical
Pathologists, Chicago, IL, Apr. 1997},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1997a,
author = {Bassler, Thomas and Kunnel, Binitha and Orozco, Roberto and O'Dowd,
Gerard},
title = {Relation between age and cancer detection in repeat prostate biopsies
following a diagnosis of high grade prostatic intraepithelial neoplasia},
booktitle = {Fall Meeting of the American Society of Clinical Pathologists},
year = {1997},
address = {Philadelphia, PA},
month = {Sep.1997},
lu_pub_type = {c_abstract},
lu_note = {check (abstract format looks more like uscap 1998)},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Bassler1997a.pdf},
file = {Bassler1997a.pdf:Bassler1997a.pdf:PDF},
owner = {U},
timestamp = {2010.12.03}
}
@article{Orozco1997b,
author = {Orozco, R and Kunnel, B and O'Dowd, G},
title = {Post-radical prostatectomy biopsies of the prostatic fossa},
journal = {Mod Pathol},
year = {1997},
volume = {10},
pages = {84A (Abstr. No. 481)},
note = {Presented at the 86th Annual Meeting of the United States and Canadian
Academy of Pathology, Orlando, Florida, Mar. 1-7, 1997},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1997b.pdf},
file = {Orozco1997b.pdf:Orozco1997b.pdf:PDF},
owner = {U},
timestamp = {2010.11.17}
}
@article{Orozco1997,
author = {Orozco, R and Schwob, V and Bassler, T and Egan, A and O'Dowd, G
and Bostwick, D},
title = {The diagnosis of ``suspicious'' for adenocarcinoma in prostate biopsies:
Evaluation of follow-up biopsies},
journal = {Mod Pathol},
year = {1997},
volume = {10},
pages = {84A (Abstr. No. 482)},
note = {Presented at the 86th Annual Meeting of the United States and Canadian
Academy of Pathology, Orlando, Florida, March 1-7, 1997},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1997.pdf},
file = {Orozco1997.pdf:Orozco1997.pdf:PDF},
owner = {UsuariO},
timestamp = {2010.10.02}
}
@article{Orozco1997c,
author = {Orozco, R. and Kunnel, B. and Bassler, I. and Bassler, T},
title = {Prostate biopsies from men under 50 years of age},
journal = {Am J Clin Pathol},
year = {1997},
pages = {338 (Abstr. No. 48)},
note = {Presented at the Fall Meeting of the American Society of Clinical
Pathologists, Philadelphia, PA, Sep.1997},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@article{Orozco1997e,
author = {Orozco, R. and Kunnel, B. and Carabajal, J. and O'Dowd, G},
title = {Prostate cancer detection rate of biopsies taken after three nonpositive
attempts},
journal = {Am J Clin Pathol},
year = {1997},
pages = {337 (Abstr. No. 46)},
note = {Presented at the Fall Meeting of the American Society of Clinical
Pathologists, Philadelphia, PA, Sep.1997},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1997e.pdf},
file = {Orozco1997e.pdf:Orozco1997e.pdf:PDF},
owner = {U},
timestamp = {2010.11.17}
}
@article{Orozco1997d,
author = {Orozco, R. and Kunnel, B. and Poole, E.},
title = {Current prostate biopsy follow-up of prostatic intraepithelial neoplasia},
journal = {Am J Clin Pathol},
year = {1997},
pages = {338 (Abstr. No. 47)},
note = {Presented at the Fall Meeting of the American Society of Clinical
Pathologists, Philadelphia, PA, Sep.1997},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1998,
author = {Bassler, Thomas and Vasa, Usha and Kunnel, Binitha and Orozco, Roberto},
title = {The influence of reporting inflammation and hyperplasia on the clinician's
decision to repeat a prostate biopsy},
booktitle = {87th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1998},
address = {Boston, MA},
month = {Feb. 28 - Mar. 6},
lu_pub_type = {c_abstract},
lu_note = {check},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Bassler1998.pdf},
file = {Bassler1998.pdf:Bassler1998.pdf:PDF},
owner = {U},
timestamp = {2010.12.03}
}
@inproceedings{Iczkowski1998a,
author = {Iczkowski, K.A. and Orozco, R. and Schwob, V and Bassler, T and Bassler,
I and Kunnel, B and Bostwick, D.},
title = {The diagnosis of suspicious for adenocarcinoma in prostate biopsies:
Predictive value for cancer},
booktitle = {87th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1998},
pages = {85A (Abstr. No. 489)},
address = {Boston, MA},
month = {Feb. 28 - Mar. 6},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{ODowd1998,
author = {O'Dowd, G and Kunnel, B and Orozco, R and Veltri, R},
title = {Free/total prostate specific antigen and follow up prostate biopsies},
booktitle = {87th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1998},
pages = {85A (Abstr. No. 527)},
address = {Boston, MA},
month = {Feb. 28 - Mar. 6},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{ODowd1998a,
author = {O'Dowd, G and Orozco, R and Kunnel, B and Kochie, P},
title = {Age-adjusted PSA is likely to miss a significant number of men 60-79
years old with prostate cancer},
booktitle = {87th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1998},
pages = {85A (Abstr. No. 528)},
address = {Boston, MA},
month = {Feb. 28 - Mar. 6},
lu_pub_type = {c_abstract},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/ODowd1998a.pdf},
file = {ODowd1998a.pdf:ODowd1998a.pdf:PDF},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{ODowd1998b,
author = {O'Dowd, Gerard and Kunnel, Binitha and Orozco, Roberto},
title = {For a given prostate-specific antigen value, positive prostate biopsy
rate increases with age},
booktitle = {87th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1998},
address = {Boston, MA},
month = {Feb. 28 - Mar. 6},
lu_pub_type = {c_abstract},
lu_note = {check},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/ODowd1998b.pdf},
file = {ODowd1998b.pdf:ODowd1998b.pdf:PDF},
owner = {U},
timestamp = {2010.12.02}
}
@inproceedings{Orozco1998b,
author = {Orozco, Roberto and Kunnel, Binitha and Vasa, Usha and Poole, Edward},
title = {The yield of repeat prostate biopsies},
booktitle = {87th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1998},
address = {Boston, MA},
month = {Feb. 28 - Mar. 6},
lu_pub_type = {c_abstract},
lu_note = {check},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1998b.pdf},
file = {Orozco1998b.pdf:Orozco1998b.pdf:PDF},
owner = {U},
timestamp = {2010.12.02}
}
@inproceedings{Orozco1998c,
author = {Orozco, Roberto and O'Dowd, Gerard and Kunnel, Binitha and Veltri,
Robert},
title = {Prostate biopsy trends},
booktitle = {87th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1998},
address = {Boston, MA},
month = {Feb. 28 - Mar. 6},
lu_pub_type = {c_abstract},
lu_note = {check},
eprint = {http://www.uropatologia.com/publicaciones/scanned_abstracts/Orozco1998c.pdf},
file = {Orozco1998c.pdf:Orozco1998c.pdf:PDF},
owner = {U},
timestamp = {2010.12.03}
}
@inproceedings{Bassler1999a,
author = {Bassler, T and Bassler, I and Kunnel, B and Holmboe, M.C. and Orozco,
R},
title = {Should the upper limit of normal PSA be lowered?},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1999b,
author = {Bassler, T and Bassler, I and Kunnel, B and Holmboe, M.C. and Orozco,
R},
title = {The false positive rate of PSA decreases with age},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20 -26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1999c,
author = {Bassler, T and Bassler, I and Kunnel, B and Holmboe, MC and Orozco,
R.},
title = {Use of age specific reference ranges (ASRRs) in PSA testing},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1999f,
author = {Bassler, T and Kunnel, B and O'Dowd, G and Holmboe, M.C. and Orozco,
R.},
title = {Granulomatous prostatitis: Incidence and associated pathological
findings},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
lu_note = {check},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1999g,
author = {Bassler, T and O'Dowd, G and Kunnel, B and Bassler, I and Holmboe,
M.C. and Orozco, R},
title = {Granulomatous prostatitis: Biopsy findings},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
lu_note = {check},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1999,
author = {Bassler, T and Orozco, R and Miller, M.C. and Veltri, R},
title = {The predictive value of PIN for prostate cancer is age-dependent},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1999e,
author = {Bassler, T and Orozco, R and Miller, M.C. and Veltri, R},
title = {Results of serial prostate biopsies. Prediction value for cancer
of age, PSA, DRE, and PIN},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Bassler1999d,
author = {Bassler, T.J. and Holmboe, M.C. and Kunnel, B and O'Dowd, G and Orozco
R},
title = {Trends in ages of patients undergoing prostate biopsies. Analysis
of over 110,000 cases nationwide over the past five years},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{ODowd1999,
author = {O'Dowd, G and Orozco, R and Kunnel, B and Bassler, T},
title = {Prostate biopsies in men under 50 years old},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{ODowd1999a,
author = {O'Dowd, G.J. and Bassler, T and Orozco, R and Holmboe, M.C. and Bane,
B.L. and Hopkins, S.},
title = {The efficacy of free/total prostate-specific antigen ratio is reduced
in association with granulomatous prostatitis},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Orozco1999,
author = {Orozco, R and Bassler, T and Veltri, R},
title = {Prostate biopsies from patients 40 years of age or younger},
booktitle = {88th Annual Meeting of the United States and Canadian Academy of
Pathology},
year = {1999},
address = {San Francisco, CA},
month = {Mar. 20-26},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Cabrera2001,
author = {Cabrera, O and Orozco, R},
title = {Angiomiolipomas renales},
booktitle = {1er Congreso de Residentes de Patolog\'{i}a},
year = {2001},
address = {IGSS, Guatemala},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.17}
}
@inproceedings{Orozco2007g,
author = {Roberto Orozco},
title = {P\'{o}lipos estromales fibroepiteliales at\'{i}picos del c\'{e}rvix
y la vagina},
booktitle = {XXVI Congreso Centroamericano de Patolog\'{i}a},
year = {2007},
address = {La Ceiba, Honduras},
month = {Nov. - Dec.},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.16}
}
@inproceedings{GramajoRodas2008,
author = {Marisol {Gramajo Rodas} and Victor Argueta and Roberto Orozco and
Werner {De Le\'{o}n}},
title = {Coriocarcinoma neonatal hep\'{a}tico. A pr\'{o}posito de un caso.},
booktitle = {XXVIII Congreso Centroamericano de Patolog\'{i}a},
year = {2008},
address = {San Jos\'{e}, Costa Rica},
month = {Nov. 26-29},
lu_pub_type = {c_abstract},
institution = {Departamento de Anatom\'{i}a Patol\'{o}gica, Hospital General San
Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{Orozco2008,
author = {Orozco, Roberto},
title = {Casos de tumores infrecuentes de la pelvis renal},
booktitle = {XXVIII Congreso Centroamericano de Patolog\'{i}a},
year = {2008},
address = {San Jos\'{e}, Costa Rica},
month = {Nov. 26-29},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{OrozcoFlorian2008,
author = {Roberto Elfidio {Orozco Flori\'{a}n} and Marisol Gramajo and Werner
{De Le\'{o}n} and Victor Argueta and Estela Ar\'{e}valo.},
title = {Enfermedad renal poliqu\'{i}stica autos\'{o}mica recesiva en gemelos},
booktitle = {XXVIII Congreso Centroamericano de Patolog\'{i}a},
year = {2008},
address = {San Jos\'{e}, Costa Rica},
month = {Nov. 26-29},
lu_pub_type = {c_abstract},
institution = {Departamento de Anatom\'{i}a Patol\'{o}gica, Hospital General San
Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{ArguetaSandoval2008,
author = {Victor Leonel {Argueta Sandoval} and Marisol Gramajo and Roberto
Orozco and Werner {De Le\'{o}n}},
title = {Sirenomelia. A pr\'{o}posito de un caso.},
booktitle = {XXVIII Congreso Centroamericano de Patolog\'{i}a},
year = {2008},
address = {San Jos\'{e}, Costa Rica},
month = {Nov. 26-29},
lu_pub_type = {c_abstract},
institution = {Departamento de Anatom\'{i}a Patol\'{o}gica, Hospital General San
Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{DeLeonPerez2008,
author = {Werner Ra\'{u}l {De Le\'{o}n P\'{e}rez} and Marisol Gramajo and Victor
Argueta and Roberto Orozco},
title = {Malformaci\'{o}n vascular esofago-g\'{a}strica. A prop\'{o}sito de
un caso.},
booktitle = {XXVIII Congreso Centroamericano de Patolog\'{i}a},
year = {2008},
address = {San Jos\'{e}, Costa Rica},
month = {Nov. 26-29},
lu_pub_type = {c_abstract},
institution = {Departamento de Anatom\'{i}a Patol\'{o}gica, Hospital General San
Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{ArguetaSandoval2009,
author = {Argueta Sandoval, Victor Leonel and Orozco F., Roberto E. and Castillo
G., Luis Oswaldo and Saravia, Marcos},
title = {Angiostrongyliasis abdominal: 24 casos de estudios de patolog\'{i}a
quir\'{u}rgica},
booktitle = {X Congreso Virtual Hispanoamericano de Anatom\'{i}a Patol\'{o}gica.},
year = {2009},
month = {Nov.},
note = {caso no. 1757},
lu_pub_type = {c_abstract},
abstract = {INTRODUCCIÓN: Angiostrongylus Costaricensis es un nemátodo metastrongilideo
que puede parasitar al hombre y que puede causar el cuadro llamado
Angiostrongyliasis abdominal. El parásito puede infectar muchas especies
de roedores, que son considerados los huéspedes definitivos, siendo
los moluscos huéspedes intermediarios y el hombre se le considera
un huésped accidental.
Las lesiones en el hombre, se presentan principalmente a nivel de
la región ileo-cecal, pero se han reportado lesiones desde el Yeyuno
hasta el Colon descendente, asi como en otras regiones.
MATERIAL Y MÉTODOS: Se revisaron informes de anatomía patológica del
Departamento de patología del Hospital General “San Juan de Dios”
de Guatemala, del año 1999 al 2008. Se localizaron los diagnósticos
de Angiostrongyliasis abdominal y se tomaron en cuenta para la revisión,
todos los que tuvieron laminillas con cortes histológicos y bloques
de parafina con tejido incluido. Se analizaron los informes de patología,
para los hallazgos macroscópicos. Se revisaron los expedientes clínicos
de 12 casos y los cortes histológicos de todos los casos.
RESULTADOS: Todos los casos correspondieron a emergencias quirúrgicas
abdominales. La edad de los pacientes osciló de 1 a 74 años. De sexo
masculino fueron 17(71%) y de sexo femenino 7(29\%). De los doce
casos que se revisaron expedientes clínicos, los leucocitos eosinófilos
variaron de 2\% hasta 51\%, con un promedio del 11\%.
Las piezas quirúrgicas fueron 6 Apéndices cecales, 7 resecciones de
Ileon terminal, 10 resecciones Ileo-cólicas y 1 resección de Yeyuno.
Con un Apéndice cecal se recibió una biopsia de Ileon y con otra
una biopsia de Ciego. Los hallazgos macroscópicos mostraron 8 con
engrosamiento de la pared, con afección de serosa y meso; 11 con
perforaciones. A nivel de mucosa, hubo 6 casos con ulceración, 4
con patrón de empedrado y 5 con marcado aplanamiento. En el estudio
histológico, los hallazgos más importantes fueron cambios vasculares,
con vasculitis fibrinoide y granulomatosa, células gigantes, granulomas
y denso infiltrado de leucocitos eosinófilos en forma difusa. Hubo
3 casos con necrosis transmural. En todos los casos se encontraron
parásitos o huevos dentro de vasos, en la mayoría se encontraron
huevos, larvas y parásitos adultos.
DISCUSIÓN-CONCLUSIONES: En nuestro trabajo podemos observar que la
mayoría de casos se presentaron en la región ileo-cecal. Todos los
casos se presentaron como una emergencia quirúrgica abdominal y en
los estudios de laboratorio, de los expedientes revisados, en la
mayoría se encontró eosinofilia.
El estudio histológico mostró los hallazgos de infiltrado denso de
eosinófilos, formación de granulomas, cambios vasculares, con vasculitis
fibrinoide y granulomatosa, mas la presencia de parásitos o huevos
en luz de vasos.},
file = {ArguetaSandoval2009.pdf:ArguetaSandoval2009.pdf:PDF},
isbn = {978-84-692-76778},
owner = {U},
timestamp = {2010.11.16},
url = {http://www.conganat.org/10congreso/vistaImpresion.asp?id_trabajo=1757
}
}
@inproceedings{Chanquin2009,
author = {Clara Chanqu\'{i}n and Victor Argueta and Roberto Orozco and Ingrid
Barrios},
title = {Citolog\'{i}a del canal anal en mujeres con VIH},
booktitle = {XXVII Congreso de la Sociedad Latinoamericana de Patolog\'{i}a},
year = {2009},
address = {Antigua Guatemala, Guatemala},
month = {Nov. 2-6},
lu_pub_type = {c_abstract},
institution = {Departamentos de Patolog\'{i}a y Ginecolog\'{i}a y Obstetricia, Hospital
General San Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{Arevalo2009a,
author = {Estela Ar\'{e}valo and Roberto Orozco and Victor Argueta and Pedro
Hern\'{a}ndez},
title = {Cistoadenoma mucinoso gigante. Presentaci\'{o}n de un caso},
booktitle = {XXVII Congreso de la Sociedad Latinoamericana de Patolog\'{i}a},
year = {2009},
address = {Antigua Guatemala, Guatemala},
month = {Nov. 2-6},
lu_pub_type = {c_abstract},
institution = {Departamentos de Anatom\'{i}a Patol\'{o}gica y Ginecolog\'{i}a y
Obstetricia, Hospital General San Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{Arevalo2009,
author = {Estela Ar\'{e}valo and Victor Argueta and Roberto Orozco and Silvia
Gil and Ricardo Mena},
title = {Hallazgos en necropsias de pacientes con influenza A H1N1},
booktitle = {XXVII Congreso de la Sociedad Latinoamericana de Patolog\'{i}a},
year = {2009},
address = {Antigua Guatemala, Guatemala},
month = {Nov. 2-6},
lu_pub_type = {c_abstract},
institution = {Departamentos de Anatom\'{i}a Patol\'{o}gica y Epidemiolog\'{i}a,
Hospital General San Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{Ortiz2009,
author = {Marco Ortiz and Roberto Morales and Juan Lezana and Ra\'{u}l Gonz\'{a}lez
and Gustavo Gonz\'{a}lez and Marisol Gramajo and Roberto Orozco},
title = {Carcinoma renal de c\'{e}lulas claras contralateral metacr\'{o}nico.
Cirug\'{i}a ahorradora de nefronas. Reporte de un caso.},
booktitle = {XXVII Congreso de la Sociedad Latinoamericana de Patolog\'{i}a},
year = {2009},
address = {Antigua Guatemala, Guatemala},
month = {Nov. 2-6},
lu_pub_type = {c_abstract},
institution = {Departamentos de Urolog\'{i}a y Patolog\'{i}a, Hospital General San
Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{Gramajo2009,
author = {Marisol Gramajo and Hern\'{a}n Molina and Roberto Orozco},
title = {Linfoma testicular de c\'{e}lulas T/NK. A prop\'{o}sito de un caso.},
booktitle = {XXVII Congreso de la Sociedad Latinoamericana de Patolog\'{i}a},
year = {2009},
address = {Antigua Guatemala, Guatemala},
month = {Nov. 2-6},
lu_pub_type = {c_abstract},
institution = {Departamento de Anatom\'{i}a Patol\'{o}gica, Hospital General San
Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{Orozco2009,
author = {Roberto Orozco and Rudolf Garc\'{i}a-Gallont},
title = {Tumor rabdoide de epipl\'{o}n},
booktitle = {XXVII Congreso de la Sociedad Latinoamericana de Patolog\'{i}a},
year = {2009},
address = {Antigua Guatemala, Guatemala},
month = {Nov. 2-6},
lu_pub_type = {c_abstract},
institution = {Hospital Herrera-Llerandi},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{SaraviaFlores2009,
author = {Saravia Flores, M. and Argueta, V. and Orozco, R. and Castillo, L.},
title = {Abdominal angiostrongyliasis: 24 cases diagnosed on specimens from
surgical emergencies},
booktitle = {98th Annual Meeting of the United States and Canadian Academy of
Pathology (USCAP)},
year = {2009},
address = {Boston, MA},
month = {Mar. 7-13},
note = {Recipient of the Jerry Smith Infectious Disease Pathology Award},
lu_pub_type = {c_abstract},
abstract = {Background: Angiostrongylus costaricensis is a nematode found in the
American continent. Humans are accidental hosts. After the infection,
the parasite migrate trough the intestinal wall and reach the mesenteric
arteries of the ileocecal region. Most symptoms associated with A.
costaricensis are due to an inflammatory/ischemic reaction of the
tissues supplied by the affected vessels. Typically, the patient
presents with acute abdominal pain. Depending upon the severity of
the ischemia within the bowel, the patient can develop necrosis and
even perforation. The diagnosis of angiostrongyliasis is made trough
the histopathological confirmation of the parasite.
Design: We reviewed 24 histologically confirmed cases of abdominal
angiostrongyliasis, from 1999 to 2008. Clinical, macroscopic and
microscopic findings that could be useful for the clinician and pathologist
to diagnose this disease were searched for.
Results: There were 17 male and 7 female patients; aged 1 to 74 years
(mean 23.6). All cases presented to the emergency room as acute abdomen;
most frenquently clinical interpreted as acute appendicitis. In 5
cases, a right lower quadrant mass was palpable. The pathological
specimens derived from 6 appendectomies, 7 terminal ileum resections,
10 ileo-colic resections and 1 yeyunal resection. One patient needed
re-intervention 10 weeks later due to another intestinal perforation.
Macroscopically, the external surface of the specimens showed vascular
congestion, fibrosis and hemorrhage. Thickening of the intestinal
wall, sometimes simulating a mass, was a striking feature. Mucosal
findings included 5 cases with flattening of the mucosa, 6 with ulcerations
and 4 with a cobblestone pattern. Transmural necrosis or perforation
was found in 14 of the 24 cases, including 1 yeyunal perforation.
Histologically, abundant presence of eosinophils and vascular necrosis
were always distinctive findings. The amount of eggs, larvae and
adult worms varied from case to case. Some had abundant adult parasites,
larvae and eggs while others needed ample sampling to find occasional
eggs.
Conclusions: This is a large series of confirmed abdominal angiostrongyliasis
cases reported from Guatemala. It illustrates the presentation of
this disease for the clinician as well as for the surgical pathologist.
Abdominal angiostrongyliasis frequently presents as an intestinal
resection specimens with clinical history of acute abdomen. It is
important for American pathologists to recognize it due to the increase
immigration to the USA from endemic areas.
Category: Infections},
owner = {U},
timestamp = {2010.11.18},
url = {http://www.abstracts2view.com/uscap09/view.php?nu=USCAP09L_1343}
}
@inproceedings{Gil2009,
author = {Silvia Gil and Victor Argueta and Roberto Orozco},
title = {Correlaci\'{o}n de los diagn\'{o}sticos cl\'{i}nicos y postmortem
del Hospital General San Juan de Dios},
booktitle = {XXVII Congreso de la Sociedad Latinoamericana de Patolog\'{i}a},
year = {2009},
address = {Antigua Guatemala, Guatemala},
month = {Nov. 2-6},
lu_pub_type = {c_abstract},
institution = {Departamento de Anatom\'{i}a Patol\'{o}gica, Hospital General San
Juan de Dios},
owner = {U},
timestamp = {2010.11.18}
}
@inproceedings{Orozco2010b,
author = {Orozco, R.},
title = {Interpretación de biopsias prostáticas},
booktitle = {XXIX Congreso Centroamericano de Patología},
year = {2010},
address = {Panama City, Panama},
month = {Nov. 29-20, Dec. 1-2},
lu_pub_type = {c_abstract},
owner = {U},
timestamp = {2013.07.14}
}
@inproceedings{Lopez2012,
author = {Jose I Lopez and Gorka Muniz and Rosa Guarch and Natalia Camarasa
and Maria Caceres and Virginia Moreno and Lola Garcia-Prats and Roberto
Orozco.},
title = {Histological Heterogeneity of Clear Cell Renal Cell Carcinoma (CCRCC).
A Complete Morphological Analysis of 47 Tumors},
booktitle = {Annual Meeting of the United States and Canadian Academy of Pathology
(USCAP)},
year = {2012},
address = {Vancouver, BC, Canada},
month = {Mar. 17-23},
lu_pub_type = {c_abstract},
abstract = {Background: CCRCC are known to be histologically heterogeneous but
no study quantifying this fact in a large group of unselected cases
has ever been performed. There is concern that limited kidney tumor
sampling protocols in general pathology practice may give a partial
and insufficient view of tumor heterogeneity. The aim of this study
is to define and quantify the extent of tumor heterogeneity in a
series of totally sampled CCRCC.
Design: Sixty-four (64) consecutive renal cell tumors from seven hospitals
were totally sampled over a three months period in 2011. 47 (73.5%)
of this group were CCRCC. A total of 1439 H&E slides of CCRCC were
collected and reviewed applying AJCC staging and Fuhrman nuclear
grade. Cases were classified as homogeneous or heterogeneous carcinomas
depending on the presence of one or more different cell types and
grades in different areas of the same tumor. Basic clinical and pathologic
data were retrieved in all cases.
Results: Males predominated in the series (31M/16F), the average age
being 62.5 years (range 27-83). Average tumor diameter was 5.9 cm
(range 2-19) and average number of paraffin blocks per case was 30.6
(range 3-130). Organ-confined tumors were predominant (59.5%) in
the series. Twenty eight CCRCC (59.5%) were histologically heterogeneous
with the main histology consisting in Grade 1 and 2 conventional
clear and/or eosinophilic cells arranged in nests, cords and pseudoglands.
Secondary patterns in these tumors included Grade 3 and 4 areas (17
cases, 60%), sarcomatoid areas (2 cases, 7%), and oncocytoid areas
(1 case, 3.5%). Small clear cells (35.7%), necrosis (32.1%), syncytial
cells (21.4%), bony metaplasia (14,2%), and papillae (7%) were also
focally detected. Homogeneous CCRCC (19 cases, 40.5%) were all entirely
composed of conventional Grade 1 and 2 clear/eosinophilic cells.
More than one third (36%) of low grade (G1/2) CCRCC had minor high
grade (G3/4) areas.
Conclusions: A significant number of CCRCC are composed of different
cell types with variable grades that can be incompletely sampled
with current protocols. This fact may contribute to the unexpected
poor behaviour of some CCRCC. Our data suggest that as many as one
third of low grade CCRCC will contain high grade foci if extensively
sampled.
Category: Genitourinary (including renal tumors)},
owner = {U},
timestamp = {2013.07.14},
url = {http://www.abstracts2view.com/uscap12/view.php?nu=USCAP12L_938}
}
@inproceedings{Lou2013,
author = {Hong Lou and Guillermo Villagran and Ushie Odey and Julie Sawitzke
and David Wells and Jen Troyer and Michal Dyba and Anne Ruch and
Roberto Orozco and Victor Argueta and Eduardo Gharzouzi and Enrique
Alvirez and Michael Dean},
title = {HPV and Cervical Cancer in Guatemala and Venezuela-Low-cost screening
with NextGen sequencing},
booktitle = {Accepted for American Society of Human Genetics (ASHG) Meeting},
year = {2013},
address = {Boston, MA},
month = {Oct. 22-26},
lu_pub_type = {c_abstract},
abstract = {High-risk human papillomavirus infections are causally related to
cervical cancer development. Cervical cancer represents the most
dramatic cancer health disparity of women in the world, with over
200,000 deaths annually, concentrated in poor, rural, and indigenous
populations. Guatemala and Venezuela are illustrative of this disparity
as cervical cancer is the predominant cause of cancer cases and deaths
in women. To determine the HPV viral strains in invasive tumors,
we initiated a prospective collection of invasive cervical cancer
cases with tissue collected in RNAlater. DNA-based testing has been
shown to be useful in identifying persistent carriers at risk for
cervical cancer. To determine the prevalence of HPV in women over
30, cervical swabs were collected at the time of a Pap exam and preserved
in 3ml of Scope mouthwash. A total of 351 cancer cases with an average
age of 53 (22-81 years), and 395 swabs of non-cancer cases over age
30 were obtained. We amplified the HPV L1 gene from DNA purified
from cancer tissues and cell lysates from cervical swab samples using
BS GP5+ and GP6+ primers and nested PCR was used to confirm the undetermined
samples by primer MY09/11 (1st run PCR) and BS GP5+ and GP6+ (2nd)
run PCR. DNA sequencing of HPV from tumor tissue revealed detectable
in HPV in 96% of samples with HPV16 in 53%, HPV18 in 12%, HPV45 in
10% and HPV 26, 31, 33, 35, 39, 52, 56, 58, 67, 68, 69, and 73 in
0.8-4.9% of samples. The prevalence of HPV infection in women without
cancer is approximately 12%. To employ NextGen sequencing for HPV
determination we bar-coded the same BS GP5+ and GP6+ primers and
sequenced on the Ion Torrent PGM. An average of 8000 reads were
obtained for each sample. Highly comparable data was obtained as
from the conventional sequencing and mixtures of HPV types as well
as polymorphisms within the isolates was observed. From the HPV16
and HPV18 samples, oncoprotein E6 and E7 RNA was quantitated to estimate
viral load. In conclusion, vaccination against HPV16 and HPV18 can
protect for up to 70% of invasive cervical cancers, but active screening
will be required for many years. A sensitive and low cost approach
to cervical sampling, including Next-Gen sequencing has been developed
that could be employed to reduce the burden of cervical cancer worldwide.},
owner = {U},
timestamp = {2013.07.14}
}
@electronic{MolinaKirsch2005a,
author = {Molina Kirsch, H and Orozco Florian, R},
month = {Nov. 13},
year = {2005},
title = {Neoplasia inusual en biopsias transrectales de pr\'{o}stata / Uncommon
prostatic neoplasia on transrectal biopsies},
howpublished = {Pat-UniNet: Foro de diagn\'{o}stico por imagen / Diagnostic Imaging
Forum},
url = {http://pat.uninet.edu/zope/pat/casos/C203/index.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.16}
}
@electronic{MolinaKirsch2005,
author = {Molina Kirsch, H and Orozco Florian, R and Ruiz Moreno, L},
month = {Oct. 24},
year = {2005},
title = {Adenopat\'{i}a cervical derecha en ni\~{n}o de 8 a\~{n}os / Right
cervical adenopathy in a eight year old male},
howpublished = {Pat-UniNet: Foro de diagn\'{o}stico por imagen / Diagnostic Imaging
Forum},
url = {http://pat.uninet.edu/zope/pat/casos/C200/index.html
},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.16}
}
@electronic{MolinaKirsch2006,
author = {{Molina Kirsch}, Hern\'{a}n and {Orozco Florian}, Roberto},
month = {Jan. 24},
year = {2006},
title = {Biopsias de p\'{o}lipos rectales / Rectal polyps biopsies},
howpublished = {Pat-UniNet: Foro de diagn\'{o}stico por imagen / Diagnostic Imaging
Forum},
url = {http://pat.uninet.edu/zope/pat/casos/C213/index.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.16}
}
@electronic{Orozco2007a,
author = {Roberto Orozco},
month = {Sep. 17},
year = {2007},
title = {Mixed epithelial and stromal tumor of the kidney},
howpublished = {International Society of Urological Pathology},
organization = {International Society of Urological Pathology},
url = {http://pathology2.jhu.edu/isup/case.cfm?caseid=199},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.15}
}
@electronic{Orozco2007b,
author = {Roberto Orozco},
month = {Sep. 10},
year = {2007},
title = {Urethral melanoma arising in glans penis melanosis},
howpublished = {International Society of Urological Pathology},
organization = {International Society of Urological Pathology},
url = {http://pathology2.jhu.edu/isup/case.cfm?caseid=197},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.15}
}
@electronic{Orozco2007c,
author = {Roberto Orozco},
month = {Jul. 09},
year = {2007},
title = {Clear cell renal cell carcinoma with rhabdoid features},
howpublished = {International Society of Urological Pathology},
organization = {International Society of Urological Pathology},
url = {http://pathology2.jhu.edu/isup/case.cfm?caseid=188},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.15}
}
@electronic{Orozco2007d,
author = {Roberto Orozco},
month = {May 21},
year = {2007},
title = {Extensive sclerosing adenosis of the prostate},
howpublished = {International Society of Urological Pathology},
organization = {International Society of Urological Pathology},
url = {http://pathology2.jhu.edu/isup/case.cfm?caseid=181},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.15}
}
@electronic{Orozco2007e,
author = {Roberto Orozco},
month = {May 28},
year = {2007},
title = {Inflammatory myofibroblastic tumor of the ureter},
howpublished = {International Society of Urological Pathology},
organization = {International Society of Urological Pathology},
url = {http://pathology2.jhu.edu/isup/case.cfm?caseid=182},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.15}
}
@electronic{Orozco2007f,
author = {Roberto Orozco},
month = {May 14},
year = {2007},
title = {Verrucous carcinoma of the urinary bladder unrelated to bilharziasis},
howpublished = {International Society of Urological Pathology},
organization = {International Society of Urological Pathology},
url = {http://pathology2.jhu.edu/isup/case.cfm?caseid=180},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.15}
}
@electronic{Gramajo2010,
author = {Marisol Gramajo and Marco Ortiz and Roberto Orozco},
month = {Jun. 24},
year = {2010},
title = {Metaplasia escamosa queratinizante del tracto urinario superior /
Colesteatoma renal},
howpublished = {Pathos.es - SIAU},
note = {Caso 2 SIAU: Masa en pelvis renal izquierda},
url = {http://www.pathos.es/casos-de-la-s.i.a.u/caso-2-siau-masa-en-pelvis-renal-izquierda/},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2010.11.16}
}
@electronic{Orozco2010,
author = {Orozco, Roberto and Gramajo, Marisol, and Ar\'{e}valo, Estela},
month = {Dec. 25},
year = {2010},
title = {Gemelos con ri\~{n}ones poliqu\'{i}sticos},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Hospital General San Juan de Dios, Guatemala},
url = {http://www.uropatologia.com/casos/caso_0001_gemelos.html},
lu_pub_type = {d_online_cases},
abstract = {Gemelos masculino y femenino de 34 semanas por Ballard, recién nacidos
por cesárea debido a presentación podálica. Ambos pacientes fueron
diagnosticados radiológicamente con riñones poliquísticos.},
owner = {U},
timestamp = {2011.01.16}
}
@electronic{Orozco2010a,
author = {Orozco, Roberto and Morales Ruis, Mario Roberto},
month = {Dec. 27},
year = {2010},
title = {Epidermoid cyst of the testis: Organ preserving surgery},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Herrera Llerandi Hospital, Guatemala},
url = {http://www.uropatologia.com/casos/caso_0002_cyst.html},
lu_pub_type = {d_online_cases},
abstract = {A 17-year old man presented with an asymptomatic right testicular
mass.},
owner = {U},
timestamp = {2011.01.16}
}
@electronic{Arevalo2011,
author = {Ar\'{e}valo, Estela and De Le\'{o}n, Werner and Orozco, Roberto},
month = {Jan. 30},
year = {2011},
title = {Carcinoma Quístico de Células Renales},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Hospital General San Juan de Dios, Guatemala},
url = {http://www.uropatologia.com/casos/caso_0004_quist.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Castillo2011,
author = {Castillo, Luis and Molina-Kirsch, Hern\'{a}n and Orozco, Roberto},
month = {Feb. 12},
year = {2011},
title = {Leiomioma Intratesticular},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Laboratorio de Patología del Dr. Luis Castillo, Guatemala},
url = {http://www.uropatologia.com/casos/caso_0005_leio.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011a,
author = {Orozco, Roberto},
month = {Feb. 21},
year = {2011},
title = {Cuerpos Glomeruloides},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0006_glomeruloide.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011b,
author = {Orozco, Roberto},
month = {Apr. 29},
year = {2011},
title = {Car\'{u}ncula Uretral Asociada a Uretritis Glandular},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0008_caruncula.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011c,
author = {Orozco, Roberto},
month = {May 4},
year = {2011},
title = {Carcinoma Urotelial In-Situ, Primario},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0009_primario.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011d,
author = {Orozco, Roberto},
month = {May 17},
year = {2011},
title = {Carcinoma Cromof\'{o}bico de C\'{e}lulas Renales},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0010_cromofobico.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011e,
author = {Orozco, Roberto},
month = {May 25},
year = {2011},
title = {Papiloma de la Vejiga Urinaria},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0011_papiloma.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011f,
author = {Orozco, Roberto},
month = {Jun. 11},
year = {2011},
title = {Masa Testicular en Paciente de 5 Meses},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0013_teratoma_testicular_puro.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011g,
author = {Orozco, Roberto},
month = {Jul. 10},
year = {2011},
title = {Carcinoma de C\'{e}lulas Escamosas de Vejiga Urinaria},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0017_carcinoma_celulas_escamosas_vejiga.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011h,
author = {Orozco, Roberto},
month = {Jul. 24},
year = {2011},
title = {Pielitis Qu\'{i}stica y Glandular},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0019_pielitis_cistica_glandular.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011k,
author = {Orozco, Roberto},
month = {Mar. 7},
year = {2011},
title = {Carcinoma de Conductos Colectores y Carcinoma In-Situ del Urotelio
de la Pelvis Renal},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Hospital General San Juan de Dios, Guatemala},
url = {http://www.uropatologia.com/casos/caso_lib_0004_conductos.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011l,
author = {Orozco, Roberto},
month = {Apr. 17},
year = {2011},
title = {¿Tumor de Tejidos Blandos del Ri\~{n}\'{o}n?},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Departamento de Patolog\'{i}a, Hospital General San Juan De Dios,
Guatemala},
url = {http://www.uropatologia.com/foro_wp/?p=44},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011j,
author = {Orozco, Roberto and Morales, Mario Roberto},
month = {Sep. 4},
year = {2011},
title = {Adenocarcinoma de la Vejiga Urinaria},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Servicios de Patolog\'{i}a y Urolog\'{i}a, Hospital Herrera LLerandi,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0023_adenocarcinoma_vejiga_urinaria.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011,
author = {Orozco, Roberto and Pérez-Luque, Luis Arturo},
month = {Jan. 19},
year = {2011},
title = {P\'{o}lipo de la Vejiga Urinaria},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Hospital Herrera Llerandi, Guatemala},
url = {http://www.uropatologia.com/casos/caso_0003_polipo.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@electronic{Orozco2011i,
author = {Orozco, Roberto and Vel\'{a}squez, Salvador},
month = {Aug. 21},
year = {2011},
title = {Paraganglioma de Ra\'{i}z Nerviosa},
howpublished = {Uropatolog\'{i}a en L\'{i}nea},
organization = {Servicios de Patolog\'{i}a y Cirug\'{i}a, Hospital Herrera LLerandi,
Guatemala},
url = {http://www.uropatologia.com/casos/caso_0022_paraganglioma_raiz_nerviosa.html},
lu_pub_type = {d_online_cases},
owner = {U},
timestamp = {2011.09.18}
}
@mastersthesis{Orozco1979,
author = {Orozco, Roberto},
title = {Biopsia renal percut\'{a}nea},
school = {Universidad de San Carlos de Guatemala},
year = {1979},
lu_pub_type = {e_thesis},
owner = {U},
timestamp = {2010.12.03}
}
@mastersthesis{Orozco-Florian1989,
author = {Orozco-Florian, Roberto Elfidio},
title = {Motor units of partially denervated triceps surae muscles of the
cat},
school = {University of Alberta},
year = {1989},
lu_pub_type = {e_thesis},
abstract = {Thesis (M. Sc.)--University of Alberta, 1987.},
institution = {OCLC's Experimental Thesis Catalog [http://alcme.oclc.org/xtcat/servlet/OAIHandler]
(United States)},
owner = {UsuariO},
publisher = {Ottawa :National Library of Canada,},
timestamp = {2010.10.02}
}
@article{Gordon2001,
author = {Gordon, Tessa and Rafuse, Victor F},
title = {Size of myelinated nerve fibres is not increased by expansion of
the peripheral field in cats},
journal = {The Journal of Physiology},
year = {2001},
volume = {532},
pages = {835-849},
number = {3},
lu_pub_type = {h_collaborations},
eprint = {http://jp.physoc.org/content/532/3/835.full.pdf+html},
abstract = {This study tests the hypothesis that target size regulates the size
of myelinated sensory and motor fibres in peripheral nerves. Cat
medial gastrocnemius (MG) muscles were partially denervated and the
size of the remaining nerve fibres that sprouted was examined 6.4
± 0.9 months later to determine whether nerve fibre size increased
with target size.Electrophysiological and morphometric analyses were
used to quantify myelinated nerve fibre size. Charge measurements
from dorsal and ventral roots were used to electrophysiologically
quantify the relative number of cut nerve fibres and the average
size of the remaining intact sensory and motor nerve fibres. Medial
gastrocnemius muscle and motor unit forces provided indirect measurements
of the increase in target size. Conduction velocities and amplitude
of unitary action potentials of motor nerve fibres innervating single
motor units were also measured after partial denervation.Electrophysiological
measurements of nerve fibre size and morphometric measurements of
outer fibre perimeters and fibre areas concurred and demonstrated
that myelinated nerve fibres supplying partially denervated MG muscles
did not increase in size in parallel with the increase in the target
size.Thus, unlike non-myelinated nerve fibres, the size of myelinated
nerve fibres does not increase as target size increases. Retrograde
control of size in non-myelinated but not in myelinated nerve fibres
demonstrates differences in plasticity of neurons in the somatic
and autonomic nervous systems.},
doi = {10.1111/j.1469-7793.2001.0835e.x},
file = {Gordon2001.pdf:Gordon2001.pdf:PDF},
owner = {U},
timestamp = {2010.12.03},
url = {http://jp.physoc.org/content/532/3/835.abstract}
}
@article{Egevad2005a,
author = {Egevad, Lars and Allsbrook, William C, Jr and Epstein, Jonathan I},
title = {Current practice of diagnosis and reporting of prostatic intraepithelial
neoplasia and glandular atypia among genitourinary pathologists},
journal = {Mod Pathol},
year = {2005},
volume = {19},
pages = {180--185},
number = {2},
month = dec,
lu_pub_type = {h_collaborations},
doi = {10.1038/modpathol.3800522},
file = {Egevad2005a.pdf:Egevad2005a.pdf:PDF},
issn = {0893-3952},
owner = {U},
timestamp = {2010.11.18},
url = {http://dx.doi.org/10.1038/modpathol.3800522}
}
@article{Egevad2005,
author = {Lars Egevad and William C. {Allsbrook Jr.} and Jonathan I. Epstein},
title = {Current practice of Gleason grading among genitourinary pathologists},
journal = {Human Pathology},
year = {2005},
volume = {36},
pages = {5 - 9},
number = {1},
lu_pub_type = {h_collaborations},
abstract = {Summary There is consensus that the Gleason system should be used
for grading of prostate cancer. However, a number of controversial
issues remain as regards how this grading is applied. A questionnaire
was sent to 91 genitourinary pathologists in countries around the
world with the purpose to survey current practice of Gleason grading.
The response rate was 74\%, including 43 North American pathologists
and 24 from other continents. Of all participants, only 13\% and
36\%, respectively, ever diagnosed a Gleason score (GS) of 2 to 3
or 4 on needle biopsies (NBX), and 88\% of those who did so assigned
a GS 4 to <1\% of cancers. Cribriform Gleason pattern (GP) 3 was
acknowledged by 88\% but a majority of them would classify <=20\%
of cribriform patterns as GP 3. One third only accepted cribriform
or fusion patterns as GP 4, but two thirds also included incomplete
or poorly defined glands. For GP 5 to be identified on NBX, 83\%
required clusters of individual cells, strands, or nests seen at
less than ×40 lens magnification. Only 26\% defined GS on NBX as
primary + tertiary GP, and a majority would mention a tertiary pattern
separately. For NBX, global or highest GS was reported by 40\% and
10\%, respectively, whereas 46\% only gave a separate GS for each
individual NBX core. In conclusion, there is a need to standardize
practical application of Gleason grading both in terms of interpretation
of patterns as well as how grading is reported. Our survey data provide
information to general pathologists about the most common grading
practices among genitourinary pathologists.},
doi = {10.1016/j.humpath.2004.10.001},
file = {Egevad2005.pdf:Egevad2005.pdf:PDF},
issn = {0046-8177},
keywords = {Prostatic neoplasms/pathology},
owner = {UsuariO},
timestamp = {2010.10.02},
url = {http://www.sciencedirect.com/science/article/B6WGD-4F31PPP-1/2/cefd49aef487e0dccd9b1fcd13b8d855}
}
@article{Egevad2010,
author = {Egevad, Lars and Srigley, John R and Delahunt, Brett},
title = {International Society of Urological Pathology (ISUP) consensus conference
on handling and staging of radical prostatectomy specimens: Rationale
and organization},
journal = {Mod Pathol},
year = {2010},
month = aug,
lu_pub_type = {h_collaborations},
abstract = {The 2009 International Society of Urological Pathology consensus conference
in Boston, made recommendations regarding the standardization of
pathology reporting of radical prostatectomy specimens. The activities
of the conference were coordinated through five workgroups. The results
are presented in five separate reports covering (1) specimen handling,
(2) T2 substaging and prostate cancer volume, (3) extraprostatic
extension, lymphovascular invasion and locally advanced disease,
(4) seminal vesicles and lymph node metastases and (5) surgical margins.
In this introductory article we describe some novel features of the
organization of the consensus process. Following the completion of
a pre-meeting survey conference, participants discussed and voted
on 43 specific issues of contention relating to the pathological
reporting of radical prostatectomy specimens. Consensus, defined
as agreement by at least 65\% of participants present, was achieved
for 30 questions.},
doi = {10.1038/modpathol.2010.159},
file = {Egevad2010.pdf:Egevad2010.pdf:PDF},
issn = {1530-0285},
keywords = {adenocarcinoma, prognosis, prostate, radical prostatectomy, stage},
owner = {U},
publisher = {United States and Canadian Academy of Pathology, Inc.},
timestamp = {2010.11.16},
url = {http://dx.doi.org/10.1038/modpathol.2010.159}
}
@unpublished{Orozcoc,
author = {Orozco, R and Veltri, R and Miller, M.C. and Bassler, T},
title = {Update on first-time prostate biopsy trends: Analysis of over 150,000
cases},
note = {Submitted for publication},
lu_pub_type = {l_unpublished},
owner = {U},
timestamp = {2010.12.03}
}